Subclinical social anxiety in healthy young adults: Cortisol and subjective anxiety in response to acute stress
Abstract
There is no consensus about the pattern of cortisol release and its relationship with subjective anxiety in situations of stress in the population with social anxiety. Our aim was to determine the cortisol and subjective anxiety response in individuals with social anxiety subjected to an acute psychosocial stressor. 26 college students (58.6% males), mean age = 21.62 ± 0.43, were exposed to the stress or control adaptation of the Maastricht Acute Stress Test. Salivary cortisol and subjective anxiety were measured before, during, and after stress. Participants showed an increase in cortisol levels during the stress and post-stress phases, with a significantly higher response in those with high social anxiety. Participants with high social anxiety also showed, as a tendency, higher levels of subjective anxiety, especially in the post-stress phase. Only in the stress phase, cortisol and subjective anxiety correlated significantly in socially anxious participants. The findings support a cortisol hyperresponsiveness in a young, non-clinical population with high social anxiety. Future research should focus on the factors involved and the effects of this physiological response on health. Furthermore, the need to control social anxiety in experiments using a laboratory psychosocial stressor is highlighted.
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Almela, M., Hidalgo, V., van-der-Meij, L., Pulopulos, M. M., Villada, C. and Salvador, A. (2014). A low cortisol response to acute stress is related to worse basal memory performance in older people. Frontiers in Aging Neuroscience, 6, art. 157.
Anderson, M. A. and Hope, D. A. (2009). The relationship among social phobia, objective and perceived physiological reactivity, and anxiety sensitivity in an adolescent population. Journal of Anxiety Disorders, 23, 18-26.
Beaton, E. A., Schmidt, L. A., Ashbaugh, A. R., Santesso, D. L., Antony, M. M., McCabe, R. E., Segalowitz, S. J. and Schulkin, J. (2006). Low salivary cortisol levels among socially anxious young adults: Preliminary evidence from a selected and a non-selected sample. Personality and Individual Differences, 41, 1217-1228.
Brunello, N., den-Boer, J. A., Judd, L. L., Kasper, S., Kelsey, J. E. and Lader, M. (2000). Social phobia: diagnosis and epidemiology, neurobiology and pharmacology, comorbidity and treatment. Journal of Affective Disorders, 60, 61–74.
Caballo, V. E., Arias, B., Calderero, M., Salazar, I. C. and Irurtia, M. J. (2011). Acoso escolar y ansiedad social en niños (I): análisis de su relación y desarrollo de nuevos instrumentos de evaluación [School bullying and social anxiety in children (I): analysis of their relationship and development of new assessment instruments]. Behavioral Psychology/Psicología Conductual, 19, 591-609.
Clark, D. M. and Wells, A. (1995). A cognitive model of social phobia. The Guilford Press.
Condren, R. M., O’Neill, A., Ryan, M. C. M., Barret, P. and Thakore, J. H. (2002). HPA axis response to a psychological stressor in generalised social phobia. Psychoneuroendocrinology, 27, 693-703.
De-Rivera, L. and Abuín, M. R. (2012). LSB-50, Listado de síntomas breve [LSB-50, Brief Symptom List]. TEA Ediciones.
Dickerson, S. S. and Kemeny, M. E. (2004). Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research. Psychological Bulletin, 130, 355–391.
Espín, L., Hidalgo, V., Almela, M., Villada, C., Salvador, A. and Gómez-Amor, J. (2013). Acute pre-learning stress and declarative memory: impact of sex, cortisol response and menstrual cycle phase. Hormones and Behavior, 63, 759–765.
Espín, L., Marquina, M., Hidalgo, V., Salvador, A. and Gómez-Amor, J. (2016). No effects of psychosocial stress on memory retrieval in non-treated young students with Generalized Social Phobia. Psychoneuroendocrinology, 73, 51-62.
Furlan, P. M., DeMartinis, N., Schweizer, E., Rickels, K. and Lucki, I. (2001). Abnormal salivary cortisol levels in social phobic patients in response to acute psychological but not physical stress. Biological Psychiatry, 50, 254-259.
Goff, L., Ali, N. and Pruessner, J. (2013). Stress reactivity during evaluation by the opposite sex: comparison of responses induced by different psychosocial stress tests. McGill Science Undergraduate Research Journal, 8, 1.
Heim, C., Ehlert, U. and Hellhammer, D.H. (2000). The potential role of hypocortisolism in the pathophysiology of stress-related bodily disorders. Psychoneuroendocrinology 25, 1-35.
Hellhammer, D. H., Wüst, S. and Kudielka, B. M. (2008). Salivary cortisol as a biomarker in stress research. Psychoneuroendocrinology, 34, 163-171.
Hidalgo, V., Pulopulos, M., Puig-Perez, S., Espín, L., Gomez-Amor, J. and Salvador, A. (2015). Acute stress affects free recall and recognition of pictures differently depending on age and sex. Behavioural Brain Research, 292, 393-402.
Hines, E. A. and Brown, G. E. (1932). A standard stimulus for measuring vasomotor reactions: its application in the study of hypertension. Proceedings of the Staff Meetings of the Mayo Clinic, 7, 332.
Inglés, C. J., Martínez-Monteagudo, M. C., Delgado, B., Torregrosa, M. S., Redondo, J., Benavides, G., García-Fernández, J. M. and García-López, L. J. (2008). Prevalencia de la conducta agresiva, conducta prosocial y ansiedad social en una muestra de adolescentes españoles: un estudio comparativo [Prevalence of aggressive behavior, prosocial behavior and social anxiety in a sample of Spanish adolescents: a comparative study]. Infancia y Aprendizaje, 31, 449-461.
Kirschbaum, C., Pirke, K.M. and Hellhammer D. H. (1993). The ‘Trier Social Stress Test’: a tool for investigating psychobiological stress responses in a laboratory setting. Neuropsychobiology, 28, 76–81.
Kirschbaum, C., Prussner, J. C., Stone, A. A., Federenko, I., Gaab, J., Lintz, D., Schommer, N. and Hellhammer, D. H. (1995). Persistent high cortisol responses to repeated psychological stress in a subpopulation of healthy men. Psychosomatic Medicine, 57, 468-474.
Klimes-Dougan, B., Hastings, P. D., Granger, D. A., Usher, B. A. and Zhan-Waxler, C. (2001). Adrenocortical activity in at-risk and normally developing adolescents: Individual differences in salivary cortisol basal levels, diurnal variation, and responses to social challenges. Development and Psychopathology, 13, 695–719.
Klumbies, E., Braeuer, D., Hoyer, J. and Kirschbaum, C. (2014). The reaction to social stress in social phobia: discordance between physiological and subjective parameters. Plos One, 9, e105670.
Levin, A. P., Saoud, J. B., Strauman, T., Gorman, J. M., Fyer, A. J., Crawford, R. and Liebowitz, M. R. (1993). Responses of “generalized” and “discrete” social phobics during public speaking. Journal of Anxiety Disorders, 7, 207–221.
Lovallo, W. (1975). The cold pressor test and autonomic function: a review and integration. Psychophysiology, 12, 268–282.
Lundberg, U. (2005). Stress hormones in health and illness: The roles of work and gender. Psychoneuroendocrinology, 30, 1017-1021.
Martel, F. L., Hayward, C., Lyons, D. M., Sanborn, K., Varady, S. and Schatzberg, A. F. (1999). Salivary cortisol levels in socially phobic adolescent girls. Depression and Anxiety, 10, 25–27.
Mattick, R. P. and Clarke, J. C. (1998). Development and validation of measures of social phobia scrutiny fear and social interaction anxiety. Behaviour Research and Therapy, 36, 455-470.
Mauss, I. B., Wilhelm, F. H. and Gross, J. J. (2003). Autonomic recovery and habituation in social anxiety. Psychophysiology, 40, 648-653.
McEwen, B. S. (1998). Protective and damaging effects of stress mediators. The New England Journal of Medicine, 338, 171-179.
Moya-Albiol, L., Serrano, M. A., González-Bono, E., Rodríguez-Alarcón, G. and Salvador, A. (2005). Respuesta psicofisiológica de estrés en una jornada laboral. Psicothema, 17, 205-211.
Potts, N. L. S., Davidson, J. R. T., Krishnan, K. R. R., Doraiswamy, P. M. and Ritchie, J. C. (1991). Levels of urinary free cortisol in social phobia. Journal of Clinical Psychiatry, 52, 41–42.
Roelofs, K., van-Peer, J., Berretty, E., de-Jong, P., Spinhoven, P. and Elzinga, B. M. (2009). Hypothalamus–Pituitary–Adrenal axis hyperresponsiveness is associated with increased social avoidance behavior in social phobia. Biological Psychiatry, 65, 336-343.
Sapolsky, R. (1996). Why stress is bad for your brain. Science, 273, 749-750.
Schneier, F. R., Liebowitz, M. R., Abi-Dargham, A., Zea-Ponce, Y., Lin, S. H. and Laruelle, M. (2000). Low dopamine D(2) receptor binding potential in social phobia. American Journal of Psychiatry, 157, 457-459.
Seisdedos, N. (1988). STAI. Cuestionario de ansiedad estado-rasgo. Madrid: TEA.
Smeets, T., Cornelisse, S., Quaedflieg, C. W., Meyer, T., Jelicic, M. and Merckelbach, H. (2012). Introducing the Maastricht Acute Stress Test (MAST): a quick and non-invasive approach to elicit robust autonomic and glucocorticoid stress responses. Psychoneuroendocrinology, 37, 1998-2008.
Spielberger, C. D., Gorsuch, R. L. and Lushene, R. E. (1970). Manual for the State/Trait Anxiety Inventory. Consulting Psychologists Press.
Stein, M. B., Torgrud, L. J. and Walker, J. R. (2000). Social phobia symptoms, subtypes, and severity: Findings from a community survey. Archives of General Psychiatry, 57, 1046-1053.
Uhde, T. W., Tancer, M. E., Gelernter, C. S. and Vittone, B. J. (1994). Normal urinary free cortisol and postdexamethasone cortisol in social phobia: comparison to normal volunteers. Journal of Affective Disorders, 30, 155-161.
Vera-Villarroel, P. E., García-López, L. J. and Olivares, J. R. (2003). Fobia social: revisión de los instrumentos de evaluación validados para población de lengua española [Social phobia: review of validated assessment instruments for the Spanish-speaking population]. Revista latinoamericana de psicología, 35, 151-160.
Villada, C., Hidalgo, V., Almela, M., Mastorci, F., Sgoifo, A. and Salvador, A. (2014). Coping with an acute psychosocial challenge: behavioural and physiological responses in young women. Plos One, 9, e114640.
Wilhelm, F. H., Kochar, A. S., Roth, W. T. and Gross, J. J. (2001). Social anxiety and response to touch: incongruence between self-evaluative and physiological reactions. Biological Psychology, 58, 181–202.
Yoon, K. L. and Joormann, J. (2012). Stress reactivity in social anxiety disorder with and without comorbid depression. Journal of Abnormal Psychology, 121, 250–255.
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