Respuesta cardiovascular al estrés en pacientes con epilepsia farmacorresistente: datos preliminares


  • Alejandro Lozano-García IDOCAL/Department of Psychobiology, Psychology Center, University of Valencia (Valencia, Spain)
  • Judit Catalán IDOCAL/Department of Psychobiology, Psychology Center, University of Valencia
  • Kevin Hampel Multidisciplinary Epilepsy Unit, Neurology Service, Hospital Universitario y Politécnico La Fe (Valencia, Spain)
  • Vicente Villanueva Multidisciplinary Epilepsy Unit, Neurology Service, Hospital Universitario y Politécnico La Fe (Valencia, Spain)
  • Esperanza González-Bono IDOCAL/Department of Psychobiology, Psychology Center, University of Valencia (Valencia, Spain)
  • Irene Cano-López IDOCAL/Department of Psychobiology, Psychology Center, University of Valencia (Valencia, Spain)
Palabras clave: Epilepsia farmacorresistente, Respuesta cardiovascular, Estrés agudo, Frecuencia cardíaca, Variabilidad cardíaca


El estrés es un factor de riesgo para las enfermedades cardiovasculares en la población general. La epilepsia se ha considerado un modelo adecuado de estrés crónico, con mayor incidencia de mortalidad cardiovascular que la población general. Este estudio proporciona datos preliminares sobre la respuesta cardiovascular ante un estresor cognitivo y una evaluación neuropsicológica en pacientes con epilepsia, explorando las relaciones entre la respuesta cardiovascular y el rendimiento cognitivo dependiendo del hemisferio responsable de la epilepsia. Treinta y cinco pacientes con epilepsia farmacorresistente, 17 con el área epileptógena(AE) en el hemisferio izquierdo (LH) y 18 con AE en el hemisferio derecho (RH), se sometieron a un estres cognitivo y una evaluación neuropsicológica. La respuesta cardiovascular se registró durante toda la sesión en ambas condiciones. Los resultados mostraron que una evaluación neuropsicológica de larga duración fue capaz de producir una respuesta cardiovascular modulada por el hemisferio, con disminuciones de la frecuencia cardíaca (y aumentos del intervalo RR) más pronunciadas en el período post-evaluación en pacientes con epilepsia del HI que en pacientes con epilepsia del HD (p = .05, p = .01, respectivamente). El hemisferio del AE moderó la relación entre la respuesta cardiovascular y el rendimiento cognitivo (para todos, p < .03). Nuestros hallazgos podrían tener implicaciones clínicas desde una perspectiva preventiva, ya que sugieren que el hemisferio del AE podría ser un factor relevante en el afrontamiento del estrés en personas con epilepsia farmacorresistente.


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Cómo citar
Lozano-García, A., Catalán, J., Hampel, K., Villanueva, V., González-Bono, E., & Cano-López, I. (2021). Respuesta cardiovascular al estrés en pacientes con epilepsia farmacorresistente: datos preliminares. Anales de Psicología / Annals of Psychology, 37(3), 440–448.
Cerebro y conducta: un enfoque neurocientífico/psicofisiológico

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