PHARMACOKINETICS OF INTRAVENOUS CLAVULANIC ACID AT SINGLE DOSE IN GOATS
Abstract
A kinetic survey of potassium clavulanate has been carried after intravenous administration in goats. Results show that c1avulanate is spread in goats according to an open paltern whith two compartments whose expression is a follows: Ct = 61'5078 e-0,1453t + 28'5500 e-0,0133t mg/l. Several pharmacokinetic parameters have been studied as well as the evolution of clavulanate concentrations in the different compartments. Finally, the binding of clavulanate to plasmatic proteins of goat has been studied, resulting an average union percentage of 16.30%.Downloads
Creative Commons Attribution 4.0
The works published in this journal are subject to the following terms:
1. The Publications Service of the University of Murcia (the publisher) retains the property rights (copyright) of published works, and encourages and enables the reuse of the same under the license specified in paragraph 2.
© Servicio de Publicaciones, Universidad de Murcia, 2019
2. The works are published in the online edition of the journal under a Creative Commons Attribution-NonCommercial 4.0 (legal text). You can copy, use, distribute, transmit and publicly display, provided that: i) you cite the author and the original source of publication (journal, editorial and URL of the work), ii) are not used for commercial purposes, iii ) mentions the existence and specifications of this license.
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
3. Conditions of self-archiving. Is allowed and encouraged the authors to disseminate electronically pre-print versions (version before being evaluated and sent to the journal) and / or post-print (version reviewed and accepted for publication) of their works before publication, as it encourages its earliest circulation and diffusion and thus a possible increase in its citation and scope between the academic community. RoMEO Color: Green.
