Bajos niveles de actividad alfa-amilasa salivar predicen un número más elevado de síntomas depresivos en una muestra infantil comunitaria.

Autores/as

  • Enrique Francisco Maldonado Montero Universidad de Málaga http://orcid.org/0000-0002-9481-8019
  • María Eugenia Fernández Martín Universidad de Málaga
  • María Victoria Trianes Torres Universidad de Málaga
  • Carmen Ortiz García Hospital Virgen de la Victoria, Málaga
  • Alfredo Engüix Hospital Virgen de la Victoria, Málaga
  • Mari Nislin The Education University of Hong Kong
DOI: https://doi.org/10.6018/analesps.34.2.289741
Palabras clave: Alfa-amilasa, Cortisol, Síntomas Depresivos, Estudio Observacional Descriptivo

Resumen

Los modelos sobre la etiología de los trastornos depresivos sugieren que el inicio de un episodio depresivo es el resultado de un complejo fenómeno que se basa en la interacción entre la carga genética, factores ambientales críticos tales como eventos vitales estresantes y traumáticos, y el efecto de los cambios neuroendocrinos asociados con la respuesta de estrés. Numerosos estudios han resaltado la utilidad de los niveles matutinos de cortisol (C) como un potencial predictor de episodios depresivos. El objetivo del estudio fue comparar la efectividad del C, de la actividad/secreción de la alfa-amilasa salivar (AAs) y de su ratio para predecir la sintomatología depresiva en una muestra comunitaria de 99 niños con edades entre los 8-11 años. Dos muestras de saliva fueron obtenidas en la mañana en dos días escolares. Los profesores describieron el comportamiento de sus estudiantes usando la escala Teacher’s Report Form (TRF). Nuestros resultados indican que, con independencia del género, el mejor predictor de las puntuaciones de depresión/aislamiento y del total de alteraciones internalizadas del TRF fue mostrar bajos niveles de actividad de AAs en la mañana. Por lo tanto, esta medida salivar podría ser usada como un marcador biológico del riesgo para el desarrollo de un primer episodio de depresivo infantil.

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Biografía del autor/a

Enrique Francisco Maldonado Montero, Universidad de Málaga

Deparment of Psychobiology and Behavioral Sciences, Lecturer.

Citas

Adam, E.K., Doane, L.D., Zinbarg, R.E., Mineka, S., Craske, M.G., & Griffith, J.W. (2010). Prospective prediction of major depressive disorder from cortisol awakening responses in adolescence. Psychoneuroendocrinology, 35, 921–931. DOI: http://dx.doi.org/10.1016/j.psyneuen.2009.12.007

Ali, N., & Pruessner, J.C. (2012). The salivary alpha amylase over cortisol ratio as a marker to assess dysregulations of the stress systems. Physiology & Behavior, 106, 65–72. DOI: http://dx.doi.org/10.1016/j.physbeh.2011.10.003

Bagley, S.L., Weaver, T.L., & Buchanan, T.W. (2011). Sex differences in physiological and affective responses to stress in remitted depression. Physiology & Behavior, 104, 180–186. DOI: http://dx.doi.org/10.1016/j.physbeh.2011.03.004

Bauer, A.M., Quas, J.A., & Boyce, W.T. (2002). Associations between physiological reactivity and children’s behavior: advantages of a multisystem approach. Journal of Developmental and Behavioral Pediatrics, 23, 102–113. DOI: http://dx.doi.org/10.1097/00004703-200204000-00007

Blair, C., Granger, D., & Razza, R.P. (2005). Cortisol reactivity is positively related to executive function in preschool children attending Head Start. Child Development, 76, 554-567. DOI: http://dx.doi.org/10.1111/j.1467-8624.2005.00863.x

Braithwaite, E.C., Ramchamandani, P.G., Lane, T.A., & Murphy, S.E. (2015). Symptoms of prenatal depression are associated with raised salivary alpha-amylase levels. Psychoneuroendocrinology, 60, 163-172. DOI:http://dx.doi.org/10.1016/j.psyneuen.2015.06.013

Buchanan, T.W., Bilbas, D., & Adolphs. R. (2010). Salivary a-amylase levels as a biomarker of experienced fear. Communicative and Integrative Biology, 3, 525-527. DOI: http://dx.doi.org/10.4161/cib.3.6.12606

Chiu, S.K., Collier, C.P., Clark, A.F., & Wynn-Edwards, K.E.(2003). Salivary cortisol on ROCHE Elecsys immunoassay system: Pilot biological variation studies. Clinical biochemistry, 36, 211–214. http://dx.doi.org/10.1016/S0009-9120(02)00471-X

Chrousos, G.P. (2009). Stress and disorders of the stress

system. Nature Reviews Endocrinology, 5, 374–381. DOI: http://dx.doi.org/10.1038/nrendo.2009.106

Cubała, W.J., & Landowski, J. (2014). Low baseline salivary alpha-amylase in drug-naïve patients with short-illness-duration first episode major depressive disorder. Journal of Affective Disorders, 157, 14-17. DOI: http://dx.doi.org/10.1016/j.jad.2013.12.043

Dietrich, A., Ormel, J., Buitelaar, J.K., Verhulst, F.C., Hoekstra, P.J., & Hartman, C.A. (2013). Cortisol in the morning and dimensions of anxiety, depression, and aggression in children from a general population and clinic-referred cohort: an integrative analysis. The TRAILS study. Psychoneuroendocrinology, 38, 1281-1298. DOI: http://dx.doi.org/10.1016/j.psyneuen.2012.11.013

Ditzen, B., Ehlert, U., & Nater, U.M. (2014). Associations between salivary alpha-amylase and catecholamines - A multilevel modeling approach. Biological Psychology, 103, 15- 18. DOI: http://dx.doi.org/10.1016/j.biopsycho.2014.08.001

Domènech-Llaberia, E., Viñas, F., Pla, E., Jané, M.C., Mitjavila, M., Corbella, T., & Canals, J. (2009). Prevalence of major depression in preschool children. European Child & Adolescent Psychiatry, 18(10), 597-604. DOI: http://dx.doi.org/10.1007/s00787-009-0019-6

Dougherty, L.R., Klein, D.N., Olino, T.M., Dyson, M., & Rose, S. (2009). Increased waking salivary cortisol and depression risk in preschoolers: the role of maternal history of melancholic depression and early child temperament. Journal of Child Psychology and Psychiatry, 50, 1495–1503. DOI: http://dx.doi.org/10.1111/j.1469- 7610.2009.02116.x

Dougherty, L.R., Smith, V.C., Olino, T.M., Dyson, M.W., Bufferd, S.J., Rose, S.A., & Klein, D.N. (2013). Maternal psychopathology and early child temperament predict young children´s salivary cortisol 3 years later. Journal of Abnormal Child Psychology, 41, 531-542.

Ehlert, U., Erni, K., Hebisch, G., & Nater, U. (2006). Salivary alpha-amylase levels after yohimbine challenge in healthy men. The Journal of Clinical Endocrinology and Metabolism, 91, 5130–5133. DOI: http://press.endocrine.org/doi/abs/10.1210/jc.2006-0461

Fonseca-Pedrero, E., Paino, M., Lemos-Giráldez, S., & Muñiz, J. (2011). Prevalence and characteristics of depressive symptomatology in non-clinical adolescents. Actas Españolas de Psiquiatría, 39(4), 217-225.

Funke, R., Eichler, A., Distler, J., Golub, Y., Kratz, O., & Moll, G.H. (2015). Stress system dysregulation in pediatric generalized anxiety disorder associated with comorbid depression. Stress and Health. DOI: http://dx.doi.org/10.1002/smi.2736

Goodyer, I.M., Herbert, J., Altham, P.M.E., Pearson, J., Secher, S.M., & Shiers, H.M. (1996). Adrenal secretion during major depression in 8- to 16-year-olds, I. Altered diurnal rhythms in salivary cortisol and dehydroepiandrosterone (DHEA) at presentation. Psychological Medicine, 26, 245–256. DOI: http://dx.doi.org/10.1017/S0033291700034644

Goodyer, I.M., Herbert, J., & Altham, P.M. (1998). Adrenal steroid secretion and major depression in 8- to 16-year-olds, III. Influence of cortisol/DHEA ratio at presentation of subsequent rates of disappointing life events and persistent major depression. Psychological Medicine, 28, 265-273. DOI: http://dx.doi.org/10.1017/S0033291797006314

Halligan, S.L., Herbert, J., Goodyer, I.M., & Murray, L. (2004). Exposure to postnatal depression predicts elevated cortisol in adolescent offspring. Biological Psychiatry, 55, 376–381. DOI: http://dx.doi.org/10.1016/j.biopsych.2003.09.013

Halligan, S.L., Herbert, J., Goodyer, I., & Murray, L. (2007). Disturbances in morning cortisol secretion in association with maternal postnatal depression predict subsequent depressive symptomatology in adolescents. Biological Psychiatry, 62, 40–46. DOI: http://dx.doi.org/10.1016/j.biopsych.2006.09.011

Hamilton, J.L., Stange, J.P., Shapero, B.G., Connolly, S.L., Abramson, L.Y., & Alloy, B.L. (2013). Cognitive vulnerabilities as predictors of stress generation in early adolescence: pathway to depressive symptoms. Journal of Abnormal Child Psychology, 41, 1027-1039. DOI: http://dx.doi.org/10.1007/s10802-013-9742-z

Hamon, M., & Blier, P.(2013). Monoamine neurocircuitry in depression and strategies for new treatments. Prog. Neuro-psychopharmacology biological psychiatry, 45, 54-63. DOI: http://dx.doi.org/10.1016/j.pnpbp.2013.04.009

Kirschbaum, C., & Hellhamer, D.H. (1989). Salivary cortisol in psychobiological research: an overview. Neuropsychobiology, 22, 150-169. DOI: http://dx.doi.org/10.1159/000118611

Herbert, J., Goodyer, I.M., Altham, P.M.E., Pearson, J., Secher, S.M., & Shiers, H.M. (1996). Adrenal secretion and major depression in 8- to 16-year-olds, II. Influence of co-morbidity at presentation. Psychological Medicine, 26, 257–263. DOI: http://dx.doi.org/10.1017/S0033291700034656

Ishitobi, Y., Akiyoshi, J., Tanaka, Y., Ando, T., Okamoto, S., Kanehisa, M.,...Kodama, K. (2010). Elevated salivary α-amylase and cortisol levels in unremitted and remitted depressed patients. International Journal of Psychiatry in Clinical Practice, 14, 268- 273. DOI: http://dx.doi.org/10.3109/13651501.2010.500737

Keenan, K., Hipwell, A., Babinski, D., Bortner, J., Henneberger, A., Hinze, A., Klostermann, S., Rischall, M., & Sapotichne, B. (2013). Examining the developmental interface of cortisol and depression symptoms in young adolescent girls. Psychoneuroendocrinology, 38, 2291-2299. DOI: http://dx.doi.org/10.1016/j.psyneuen.2013.04.017

Kendler, K.S. & Gadner, C.O. (2014). Sex differences in pathways to major depression: a study of opposite twin pairs. American Journal of Psychiatry, 171, 426-435. DOI: http://dx.doi.org/10.1176/appi.ajp.2013.13101375

Kirschbaum, C., & Hellhammer, D.H. (1989). Salivary cortisol in psychobiological research: an overview. Neuropsychobiology, 22, 150–169. DOI: http://dx.doi.org/10.1159/000118611

Kiss, J.P. (2008). Theory of active antidepressants: A nonsynaptic approach to the treatment of depression. Neurochemistry International, 52, 34-39. DOI: http://dx.doi.org/10.1016/j.neuint.2007.04.006

Kuhlman, K.R., Olson, S.L., & Lopez-Duran, N.L. (2014). Predicting developmental changes in internalizing symptoms: examining the interplay between parenting and neuroendocrine stress reactivity. Developmental Psychopathology, 56, 908-923. DOI: http://dx.doi.org/10.1002/dev.21166

Lang. P., McTeague, L.M., & Bradley, M.M. (2014). Pathological anxiety and functional/dysfunction in the brain´s fear/defense circuitry. Restorative Neurology and Neuroscience, 32, 63-7. DOI: https://doi.org/10.3233/RNN-139012

Lewis, G., Jones, P.B., & Goodyer, I.M. (2016). The ROOTS study: a 10-year review of findings on adolescent depression, and recomendations for future longitudinal research. Social Psychiatry and Psychiatric Epidemiology, 124, 100-110. DOI: http://dx.doi.org/10.1007/s00127-015-1150-y

Maldonado, E.F., Fernandez, F.J., Trianes, M.V., Wesnes, K., Petrini, O., Zangara, A.,...Ambrosetti, L. (2008). Cognitive performance and morning levels of salivary cortisol and alpha-amylase in children reporting high vs. low daily stress perception. The Spanish Journal of Psychology, 11, 3–15.

Mendes, A.V., Loureiro, S.R., Crippa, J.A., de Meneses Gaya, C., García-Esteve, L., & Martín-Santos, R. (2012). Mothers with depression, school-age children with depression? A systematic review. Perspectives in psychiatric care, 48(3), 138-148. DOI: http://dx.doi.org/10.1111/j.1744-6163.2011.00318.x

Merwin, S.M., Smith, V.C., Kushner, M., Lemay, E.P. Jr., & Dougherty, L.R. (2017). Parent-child adrenocortical concordance in early childhood: The moderating role of parental depression and child development. Biological Psychology, 124, 100-110. DOI: http://dx.doi.org/10.1016/j.biopsycho.2017.01.013

Nater, U.M., & Rohleder, N. (2009). Salivary alpha-amylase as a non-invasive biomarker for the sympathetic nervous system: Current state of research. Psychoneuroendocrinology, 34, 486-496. DOI: http://dx.doi.org/10.1016/j.psyneuen.2009.01.014

Navazesh, M., (1993). Methods for collecting saliva. Annals of the New York academy of sciences, 694, 72–77. DOI: http://dx.doi.org/10.1111/j.1749-6632.1993.tb18343.x

Nederhof, E., van Oort, F.V., Bouma, E.M., Laceulle, O.M., Oldenhinkel, A.J., & Ormel, J. (2015). Predicting mental disorders from hypothalamic-pituitary-adrenal axis functioning: a 3-year follow-up in the TRAILS study. Psychogical Medicine, 45, 2403-2412. DOI: http://dx.doi.org/10.1017/S0033291715000392

Nelemans, S. A., Hale, W. W., Branje, S. J., van Lier, P. A., Jansen, L. M., Platje, E., ... & Meeus, W. H. (2014). Persistent heightened cortisol awakening response and adolescent internalizing symptoms: a 3-year longitudinal community study. Journal of abnormal child psychology, 42(5), 767-777. DOI: http://dx.doi.org/10.1007/s10802-013-9820-2

O ́Donnell, K.J., Glover, V., Jenkins, J., Browne, D., Ben-Shlomo, Y., Golding, J., & O ́Connor, T.G. (2013). Prenatal maternal mood is associated with altered diurnal cortisol in adolescence. Psychoneuroendocrinology, 38, 1630-1638. DOI: http://dx.doi.org/10.1016/j.psyneuen.2013.01.008

Owens, M., Herbert, J., Jones, P.B., Sahakian, B.J., Wilkinson, P.O., Dunn, V.J.,...Goodyer, I.M. (2014). Elevated morning cortisol is a stratified population- level biomarker for major depression in boys only with high depressive symptoms. Proceedings of the National Academy of Sciences, 111, 3638-3643. DOI: http://dx.doi.org/10.1073/pnas.1318786111

Pagliaccio, D., Luby, J. L., Bogdan, R., Agrawal, A., Gaffrey, M. S., Belden, A. C., ... & Barch, D. M. (2015). HPA axis genetic variation, pubertal status, and sex interact to predict amygdala and hippocampus responses to negative emotional faces in school-age children. NeuroImage, 109, 1-11. DOI: http://dx.doi.org/10.1016/j.neuroimage.2015.01.017

Rohleder, N., & Nater, U.M. (2009). Determinants of salivary alpha-amylase in humans and methodological considerations. Psychoneuroendocrinology, 34, 469–485. DOI: 10.1016/j.psyneuen.2008.12.004. DOI: http://dx.doi.org/10.1016/j.psyneuen.2008.12.004

Sánchez-Navarro, J.P., Maldonado, E.F., Martínez-Selva, J.M., Enguix, A., & Ortiz, C., (2012). Salivary alpha-amylase changes promoted by sustained exposure to affective pictures. Psychophysiology. 49, 1601–1609. DOI: http://dx.doi.org/10.1111/j.1469- 8986.2012.01475.x

Sapolsky, R.M. (2000). Stress hormones: good and bad. Neurobiology of Disease, 7, 540- 542. DOI: http://dx.doi.org/10.1006/nbdi.2000.0350

Tanaka, Y., Ishitobi, Y., Maruyama, Y., Kawano, A., Ando, T., Okamoto, S.,...Akiyoshi, J. (2012). Salivary alpha-amylase and cortisol responsiveness following electrical stimulation stress in major depressive disorder patients. Progress in Neuro- Psychopharmacology and Biological Psychiatry, 36, 220–224. DOI: http://dx.doi.org/10.1016/j.pnpbp.2011.10.005

Technow, J.R., Hazel, N.A., Abela, J.R.Z., & Hankin, B.L. (2015). Stress sensitivity interacts with depression history to predict depressive among youth: prospective changes following first depression onset. Journal of Abnormal Child Psychology, 43, 489-501. DOI: http://dx.doi.org/10.1007/s10802-014-9922-5

Ulrike, S., Reinhold, L., & Dirk H. (2013). Major depression in young girls is related to altered cortisol awakening response. European Child & Adolescence Psychiatry, 22, 379-384. DOI: http://dx.doi.org/10.1007/s00787-012-0371-9

Van den Bergh, B.R. & Van Calster, B. (2009). Diurnal cortisol profiles and evening cortisol in post-pubertal adolescents scoring high on the Children´s Depression Score. Psychoneuroendocrinology, 34, 791-794. DOI: http://dx.doi.org/10.1016/j.psyneuen.2008.12.008

Van Stegeren, A., Rohleder, N., Everaerd, W., & Wolf, O.T. (2006). Salivary alpha amylase as marker for adrenergic activity during stress: Effect of betablockade. Psychoneuroendocrinology, 31, 137–141. DOI: http://dx.doi.org/10.1016/j.psyneuen.2005.05.012

Veen, G., Giltay, E.J., Licht, C.M.M., Vreeburg, S.A., Cobbaert, C.M., Penninx, B.W.J.H., & Zitman, F.G. (2013). Evening salivary alpha-amylase, major depressive disorder, and antidepressant use in the Netherlands Study of Depression and Anxiety (NESDA). Psychiatry Research, 208, 41–46. DOI: http://dx.doi.org/10.1016/j.psychres.2013.03.012

Vigil, J.M., Geary, D.C., Granger, D.A., & Flinn, M.V. (2010). Sex differences in salivary cortisol, alpha-amylase, and psychological functioning following Hurricane Katrina. Child Development, 81, 1228-1240. DOI: http://dx.doi.org/10.1111/j.1467- 8624.2010.01464.x

Vogeser, M., Durner, J., Seliger, E., & Auernhammer, C., 2006. Measurement of late-night salivary cortisol with an automated immunoassay system. Clinical chemistry and laboratory medicine, 44, 1441–1445. DOI: http://dx.doi.org/10.1515/CCLM.2006.244

Vrshek-Schallhorn, S., Doane, L.D., Mineka, S., Zinbarg, R.E., Craske, M.G., & Adam, E.K. (2013). The cortisol awakening response predicts major depression: predictive stability over a 4-year follow-up and effect of depression history. Psychological Medicine, 43, 483-493. DOI: http://dx.doi.org/10.1017/S0033291712001213

Weissman, M. M., Pilowsky, D. J., Wickramaratne, P. J., Talati, A., Wisniewski, S. R., Fava, M., ... & Cerda, G. (2006). Remissions in maternal depression and child psychopathology: a STAR* D-child report. Jama, 295(12), 1389-1398.. DOI: http://dx.doi.org/10.1001/jama.295.12.1389

Publicado
10-04-2018
Cómo citar
Maldonado Montero, E. F., Fernández Martín, M. E., Trianes Torres, M. V., Ortiz García, C., Engüix, A., & Nislin, M. (2018). Bajos niveles de actividad alfa-amilasa salivar predicen un número más elevado de síntomas depresivos en una muestra infantil comunitaria. Anales de Psicología / Annals of Psychology, 34(2), 224–232. https://doi.org/10.6018/analesps.34.2.289741
Número
Sección
Psicología clínica y de la salud

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