Effects of prenatal yoga exercise on hepcidin and ferritin levels in pregnant women
Abstract
Prenatal yoga is a modification of hatha yoga tailored for pregnant women. This exercise is recommended throughout pregnancy. This study aimed to determine the effect of prenatal yoga exercise on the serum levels of hepcidin and ferritin in pregnant women. The study employed a quasi-experimental design with a pre- and post-test. A total of 134 second-trimester pregnant women participated and were divided into two groups (intervention group = 62, control group = 72). The intervention group received prenatal yoga exercises for 8 weeks (twice a week), while the control group attended only the standard pregnancy class. Each group was further divided into subgroups: anemic pregnant women, normal pregnant women, and overweight pregnant women. Demographic data were obtained through a basic questionnaire, while pre-pregnancy BMI data, obstetric history, and pregnancy examinations were sourced from the KIA book. Serum hepcidin levels significantly decreased in pregnant women who participated in prenatal yoga exercises (p=0.002), with the highest significance observed in overweight pregnant women (p=0.001). The average serum ferritin levels increased in all groups but were not statistically significant (p=0.759). Regular prenatal yoga exercises can reduce serum hepcidin levels in pregnant women, with a significant reduction noted in overweight pregnant women. Ferritin levels might be influenced by iron supplementation.
Downloads
References
Ambarish, V., Doreswamy, V., Narasipur, O. S., Kunnavil, R., & Srinivassamurthy, N. (2015). Effect of Yoga Practice on Level of Inflamatory Markers after moderate and Strenous Exercise. Journal of Clinical and Diagnostic Research, 9(6), 8–12. https://doi.org/10.7869/JCDR/2015/12851.6021
Arabin, B., & Stupin, J. H. (2014). Overweight and obesity before, during and after pregnancy. Geburtshilfe Und Frauenheilkunde, 74(7), 646–655. https://doi.org/10.1055/s-0034-1368462
Belaya, I., Kucháriková, N., Górová, V., Kysenius, K., Hare, D. J., Crouch, P. J., Malm, T., Atalay, M., White, A. R., Liddell, J. R., & Kanninen, K. M. (2021). Regular physical exercise modulates iron homeostasis in the 5xfad mouse model of alzheimer’s disease. International Journal of Molecular Sciences, 22(16), 1-17. https://doi.org/10.3390/ijms22168715
Carranque, G. A., Maldonado, E. F., Vera, F. M., Manzaneque, J. M., Blanca, M. J., Soriano, G., & Morell, M. (2012). Hematological and biochemical modulation in regular yoga practitioners. Biomedical Research, 23(2), 176–182.
Chen, P. J., Yang, L., Chou, C. C., Li, C. C., Chang, Y. C., & Liaw, J. J. (2017). Effects of prenatal yoga on women's stress and immune function across pregnancy: A randomized controlled trial. Complementary Therapies in Medicine, 31, 109–117. https://doi.org/10.1016/j.ctim.2017.03.003
Dao, M. C., Sen, S., Iyer, C., Klebenov, D., & Meydani, S. N. (2013). Obesity during pregnancy and fetal iron status: Is hepcidin the link? Journal of Perinatology, 33(3), 177–181. https://doi.org/10.1038/JP.2012.81
Behzadnezhad, N., Esfarjani, F., & Marandi, S. M. (2021). Impact of resistance training and basic ferritin on hepcidin, iron status and some inflammatory markers in overweight/obese girls. Journal of Research in Medical Sciences, 26(1), 95-95. https://doi.org/10.4103/jrms.JRMS_511_20
Fisher, A. L., & Nemeth, E. (2017). Iron homeostasis during pregnancy. The American journal of clinical nutrition, 106, 1567–1574. https://doi.org/10.3945/ajcn.117.155812
Garcia-Valdes, L., Campoy, C., Hayes, H., Florido, J., Rusanova, I., Miranda, M. T., & McArdle, H. J. (2015). The impact of maternal obesity on iron status, placental transferrin receptor expression and hepcidin expression in human pregnancy. International Journal of Obesity, 39(4), 571–578. https://doi.org/10.1038/ijo.2015.3
Govindappagari, S., & Burwick, R. M. (2019). Treatment of Iron Deficiency Anemia in Pregnancy with Intravenous versus Oral Iron: Systematic Review and Meta-Analysis. American Journal of Perinatology, 36(4), 366–376. https://doi.org/10.1055/s-0038-1668555
Hirosawa, T., Hayashi, A., Harada, Y., & Shimizu, T. (2022). The Clinical and Biological Manifestations in Women with Iron Deficiency Without Anemia Compared to Iron Deficiency Anemia in a General Internal Medicine Setting: A Retrospective Cohort Study. International Journal of General Medicine, 15, 6765–6773. https://doi.org/10.2147/IJGM.S376405
Hoffmann, C., & Weigert, C. (2017). Skeletal muscle as an endocrine organ: the role of myokines in exercise adaptations. Cold Spring Harbor Perspectives in Medicine, 7(11), 1-23.
Koenig, M. D., Tussing-Humphreys, L., Day, J., Cadwell, B., & Nemeth, E. (2014). Hepcidin and iron homeostasis during pregnancy. In Nutrients 6(8), 3062–3083. https://doi.org/10.3390/nu6083062
Means, R. T. (2020). Iron deficiency and iron deficiency anemia: Implications and impact in pregnancy, fetal development, and early childhood parameters. Nutrients, 12(2), 1-16. https://doi.org/10.3390/nu12020447
Milman, N. (2006). Iron and pregnancy - A delicate balance. Annals of Hematology, 85(9), 559–565. https://doi.org/10.1007/s00277-006-0108-2
Possamai, A., & Blasi, A. J. (2020). Serum Ferritin and Iron/TIBC of Pregnant Women Attending Nnamdi Azikiwe University Teaching Hospitasl, Nnewi, Anambra State, Nigeria: A Longitudinal Study. Clinical Research in Obstetrics and Gynecology, 3(2), 1–6. https://doi.org/10.4135/9781529714401.n258
Ray, U. S., Pathak, A., & Tomer, O. S. (2011). Hatha yoga practices: Energy expenditure, respiratory changes and intensity of exercise. Evidence-Based Complementary and Alternative Medicine, 8(6), 1-12. https://doi.org/10.1093/ecam/neq046
Sahai, N., Chandran, A. B., Bhuyan, A., Das, B., Mandal, S., & Sarma, T. (2019). Effect of yoga on physical and physiological parameters. International Journal of Innovative Technology and Exploring Engineering, 8(10), 2061–2064. https://doi.org/10.35940/ijitee.J9326.0881019
Sharma, J. B., Bumma, S. D., Saxena, R., Kumar, S., Roy, K. K., Singh, N., & Vanamail, P. (2016). Cross sectional, comparative study of serum erythropoietin, transferrin receptor, ferritin levels and other hematological indices in normal pregnancies and iron deficiency anemia during pregnancy. European Journal of Obstetrics and Gynecology and Reproductive Biology, 203, 99–103. https://doi.org/10.1016/j.ejogrb.2016.05.022
Sharma, N., & Gupta, R. (2016). A study of yoga in anemic patients. International Journal of Medical Science and Public Health, 5(03), 399–401. https://doi.org/10.5455/ijmsph.2016.0207201564
Suna, R. (2017). Effect of yogic practice and aerobic training on selected physiological variables among college women. International Journal of Physiology, Nutrition and Physical Education, 2(1), 29–31.
Woodyard, C. (2011). Exploring the therapeutic effects of yoga and its ability to increase quality of life. International Journal of Yoga, 4, 49–54. https://doi.org/10.4103/0973-6131.85485
The works and papers that are published in this Journal are subject to the following terms:
1. The Publication Service of the University of Murcia (the publisher) has the Publication Rights (Copyright) to the published papers and works, and favors and permits the reusing of the same under the license indicated in point 2.
© Servicio de Publicaciones, Universidad de Murcia, 2013
2. The papers and works are to be published in the digital edition of the Journal under the license Creative Commons Reconocimiento-No Comercial-Sin Obra Derivada 3.0 España (legal text). The copying, using, spreading, transmitting and publicly displaying of the papers, works or publication are permitted as long as: i) the authors and original sources (Journal, publisher and URL of the publication) are quoted; ii) it is not used for commercial benefit; iii) the existence and specifications of this users license are mentioned.
3. Conditions of Self-Archiving. It is permitted and encouraged that the authors spread electronically the pre-print (before printing) and/or post-print (the revised, evaluated and accepted) versions of their papers or works before their publication since this favors their circulation and early diffusion and therefore can help increase their citation and quotation, and also there reach through the academic community.
The works and papers that are published in this Journal are subject to the following terms:
1. The Publication Service of the University of Murcia (the publisher) has the Publication Rights (Copyright) to the published papers and works, and favors and permits the reusing of the same under the license indicated in point 2.
© Servicio de Publicaciones, Universidad de Murcia, 2013
2. The papers and works are to be published in the digital edition of the Journal under the license Creative Commons Reconocimiento-No Comercial-Sin Obra Derivada 3.0 España (legal text). The copying, using, spreading, transmitting and publicly displaying of the papers, works or publication are permitted as long as: i) the authors and original sources (Journal, publisher and URL of the publication) are quoted; ii) it is not used for commercial benefit; iii) the existence and specifications of this users license are mentioned.
3. Conditions of Self-Archiving. It is permitted and encouraged that the authors spread electronically the pre-print (before printing) and/or post-print (the revised, evaluated and accepted) versions of their papers or works before their publication since this favors their circulation and early diffusion and therefore can help increase their citation and quotation, and also there reach through the academic community.