Comparing the effect of aerobic exercises and guided imagery on depression in patients with multiple sclerosis

Authors

  • Hoda Z. Abd-ElRaheem Department of Physical Therapy for Neurology, Faculty of Physical Therapy, Cairo University, Cairo, Egypt.
  • Abeer A. Elwishy Department of Physical Therapy for Neurology, Faculty of Physical Therapy, Cairo University, Cairo, Egypt.
  • Hatem Samir M. Shehata Department of Neurosurgery, Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Amina Awad Department of Physical Therapy for Neurology, Faculty of Physical Therapy, Cairo University, Cairo, Egypt.
DOI: https://doi.org/10.6018/sportk.554281
Keywords: Aerobic exercise, Healing light guided imagery, Depression, Multiple Sclerosis

Abstract

Background: Depression is commonly found in multiple sclerosis (MS), yet, it still undertreated. Objective: To compare the effect of aerobic exercise and Heal Light Guided Imagery (HLGI) on depression in patients with Relapsing-Remitting MS (RRMS) at short-term and one month follow up. Methods: A parallel group trial was conducted for eight successive weeks on 45 patients with RRMS, aged between 20 to 40 years old, and randomly assigned into three groups; 15 patients each. Aerobic exercise (AE) group received 30 minutes of stationary bicycle twice weekly, HLGI group received one session (60 minutes) weekly, and a wait-list control group. The Beck Depression Inventory (BDI), Fatigue Severity Scale (FSS) and Paced Auditory Serial Addition Test (PASAT), were measured pre-treatment, post-treatment and one month follow up. Results: The BDI showed significant reduction in AE and HLGI post-treatment and at follow up, with no statistical difference between the two groups. Compared with control group, the BDI was significantly reduced in intervention groups post-treatment and at follow up, while the FSS showed significant reduction in intervention groups only post-treatment. The PASAT showed significant increase post-treatment and at follow up in all groups, with no significant difference between them. Conclusion: Aerobic exercise and HLGI can similarly reduce depression in people with RRMS.

Downloads

Download data is not yet available.

References

Ahmadi, A., Arastoo, A. A., Nikbakht, M., Zahednejad, S., & Rajabpour, M. (2013). Comparison of the effect of 8 weeks aerobic and yoga training on ambulatory function, fatigue and mood status in MS patients. Iranian Red Crescent Medical Journal, 15(6), 449-454. https://doi.org/10.5812/ircmj.3597

Al-Sharman, A., Khalil, H., El-Salem, K., Aldughmi, M., & Aburub, A. (2019). The effects of aerobic exercise on sleep quality measures and sleep-related biomarkers in individuals with Multiple Sclerosis: A pilot randomised controlled trial. NeuroRehabilitation, 45(1), 107-115. https://doi.org/10.3233/nre-192748

Alvarenga-Filho, H., Sacramento, P. M., Ferreira, T. B., Hygino, J., Abreu, J. E. C., Carvalho, S. R., ... & Bento, C. A. (2016). Combined exercise training reduces fatigue and modulates the cytokine profile of T-cells from multiple sclerosis patients in response to neuromediators. Journal of neuroimmunology, 293, 91-99. https://doi.org/10.1016/j.jneuroim.2016.02.014

Al-Sobayel, H. I., Al-Hugail, H. A., AlSaif, R. M., Albawardi, N. M., Alnahdi, A. H., Daif, A. M., & Al-Arfaj, H. F. (2016). Validation of an Arabic version of fatigue severity scale. Saudi Medical Journal, 37(1), 73-78. https://doi.org/10.15537/smj.2016.1.13055

Bahji, A., Hawken, E. R., Sepehry, A. A., Cabrera, C. A., & Vazquez, G. E. C. T. (2019). ECT beyond unipolar major depression: systematic review and meta‐analysis of electroconvulsive therapy in bipolar depression. Acta Psychiatrica Scandinavica, 139(3), 214-226. https://doi.org/10.1111/acps.12994

Beck, A. T., Ward, C. H., Mendelson, M., Mock, J., Erbaugh, J. (1961). An inventory for measuring depression. Archives of General Psychiatry, 4, 561-571. https://doi.org/10.1001/archpsyc.1961.01710120031004

Beck, A. T., Steer, R. A., & Garbin, M. G. (1988). Psychometric properties of the Beck Depression Inventory: Twenty-five years of evaluation. Clinical Psychology Review, 8(1), 77-100.

Briken, S., Gold, S. M., Patra, S., Vettorazzi, E., Harbs, D., Tallner, A., ... & Heesen, C. (2014). Effects of exercise on fitness and cognition in progressive MS: a randomized, controlled pilot trial. Multiple Sclerosis Journal, 20(3), 382-390. https://doi.org/10.1177/1352458513507358

Beitollahi, M., Forouzi, M. A., Tirgari, B., & Jahani, Y. (2022). Fatigue, stigma, and mood in patients with multiple sclerosis: effectiveness of guided imagery. BMC neurology, 22(1), 152. https://doi.org/10.1186/s12883-022-02677-3

Boeschoten, R. E., Braamse, A. M., Beekman, A. T., Cuijpers, P., van Oppen, P., Dekker, J., & Uitdehaag, B. M. (2017). Prevalence of depression and anxiety in multiple sclerosis: a systematic review and meta-analysis. Journal of the neurological sciences, 372, 331-341. https://doi.org/10.1016/j.jns.2016.11.067

Bilek, F., Cetisli-Korkmaz, N., Ercan, Z., Deniz, G., & Demir, C. F. (2022). Aerobic exercise increases irisin serum levels and improves depression and fatigue in patients with relapsing remitting multiple sclerosis: a randomized controlled trial. Multiple Sclerosis and Related Disorders, 61, 103742. https://doi.org/10.1016/j.msard.2022.103742

Braley, T. J., & Chervin, R. D. (2010). Fatigue in multiple sclerosis: mechanisms, evaluation, and treatment. Sleep, 33(8), 1061-1067. https://doi.org/10.1093/sleep/33.8.1061

Canning, K. L., & Hicks, A. L. (2020). Benefits of adhering to the Canadian physical activity guidelines for adults with multiple sclerosis beyond aerobic fitness and strength. International journal of MS care, 22(1), 15-21. https://doi.org/10.7224/1537-2073.2018-061

Case, L. K., Jackson, P., Kinkel, R., & Mills, P. J. (2018). Guided imagery improves mood, fatigue, and quality of life in individuals with multiple sclerosis: an exploratory efficacy trial of healing light guided imagery. Journal of evidence-based integrative medicine, 23, 2515690X17748744. https://doi.org/10.1177/2515690x17748744

Cortés‐Martínez, A., Matias‐Guiu, J. A., Pytel, V., Montero, P., Moreno‐Ramos, T., & Matías‐Guiu, J. (2019). What is the meaning of PASAT rejection in multiple sclerosis? Acta Neurologica Scandinavica, 139(6), 559-562. https://doi.org/10.1111/ane.13090

Compston, A., & Coles, A. (2008). Multiple sclerosis. Lancet, 372(9648), 1502–1517. https://doi.org/10.1016/s0140-6736(08)61620-7

Dalgas, U., Stenager, E., Sloth, M., & Stenager, E. (2015). The effect of exercise on depressive symptoms in multiple sclerosis based on a meta‐analysis and critical review of the literature. European journal of neurology, 22(3), 443-e34. https://doi.org/10.1111/ene.12576

Dalgas, U., Langeskov-Christensen, M., Stenager, E., Riemenschneider, M., & Hvid, L. G. (2019). Exercise as medicine in multiple sclerosis—time for a paradigm shift: preventive, symptomatic, and disease-modifying aspects and perspectives. Current neurology and neuroscience reports, 19, 1-12. https://doi.org/10.1007/s11910-019-1002-3

Diechmann, M. D., Campbell, E., Coulter, E., Paul, L., Dalgas, U., & Hvid, L. G. (2021). Effects of exercise training on neurotrophic factors and subsequent neuroprotection in persons with multiple sclerosis—a systematic review and meta-analysis. Brain sciences, 11(11), 1499. https://doi.org/10.3390/brainsci111114996

Elgit, Ö., Bilge, A., & Bayrakçı, A. (2020). Effect of guided imagery on the functionality of individuals diagnosed with schizophrenia in a community mental health center. Journal of Psychiatric Nursing, 11(3), 165-172.

Fimland, M. S., Helgerud, J., Gruber, M., Leivseth, G., & Hoff, J. (2010). Enhanced neural drive after maximal strength training in multiple sclerosis patients. European journal of applied physiology, 110, 435-443. https://doi.org/10.1007/s00421-010-1519-2

Fischer, J. S., Rudick, R. A., Cutter, G. R., Reingold, S. C., & National MS Society Clinical Outcomes Assessment Task Force. (1999). The Multiple Sclerosis Functional Composite measure (MSFC): an integrated approach to MS clinical outcome assessment. Multiple Sclerosis Journal, 5(4), 244-250. https://doi.org/10.1177/135245859900500409

Flachenecker, P., Kümpfel, T., Kallmann, B., Gottschalk, M., Grauer, O., Rieckmann, P., ... & Toyka, K. V. (2002). Fatigue in multiple sclerosis: a comparison of different rating scales and correlation to clinical parameters. Multiple Sclerosis Journal, 8(6), 523-526. https://doi.org/10.1191/1352458502ms839oa

Gronwall, D. (1977). Paced auditory serial addition task: A measure of recovery from concussion. Perceptual and Motor Skills, 44, 363–373. https://doi.org/10.2466/pms.1977.44.2.367

Gharakhanlou, R., Wesselmann, L., Rademacher, A., Lampit, A., Negaresh, R., Kaviani, M., ... & Javelle, F. (2021). Exercise training and cognitive performance in persons with multiple sclerosis: a systematic review and multilevel meta-analysis of clinical trials. Multiple Sclerosis Journal, 27(13), 1977-1993. https://doi.org/10.1177/1352458520917935

Heine, M., Verschuren, O., Hoogervorst, E. L., van Munster, E., Hacking, H. G., Visser-Meily, A., ... & TREFAMS-ACE study group. (2017). Does aerobic training alleviate fatigue and improve societal participation in patients with multiple sclerosis? A randomized controlled trial. Multiple Sclerosis Journal, 23(11), 1517-1526. https://doi.org/10.1177/1352458517696596

Heitmann, H., Andlauer, T. F., Korn, T., Mühlau, M., Henningsen, P., Hemmer, B., & Ploner, M. (2022). Fatigue, depression, and pain in multiple sclerosis: how neuroinflammation translates into dysfunctional reward processing and anhedonic symptoms. Multiple Sclerosis Journal, 28(7), 1020-1027. https://doi.org/10.1177/1352458520972279

Jones, C. D., Motl, R., & Sandroff, B. M. (2021). Depression in multiple sclerosis: Is one approach for its management enough? Multiple Sclerosis and Related Disorders, 51, 102904. https://doi.org/10.1016/j.msard.2021.102904

Kamenov, K., Mellor-Marsá, B., Leal, I., Ayuso-Mateos, J. L., Cabello, M. (2014). Analysing psychosocial difficulties in depression: a content comparison between systematic literature review and patient perspective. BioMed Research International, 2014, 319634. https://doi.org/10.1155%2F2014%2F319634

Kara, B., Küçük, F., Tomruk, M. S., & İdıman, E. (2017). Different types of exercise in multiple sclerosis: aerobic exercise or pilates, a single-blind clinical study. Journal of Back and Musculoskeletal Rehabilitation, 30(3), 565-573. https://doi.org/10.3233/bmr-150515

Krupp, L.B. (1995). The validity and reliability of the Fatigue Severity Scale in Multiple Sclerosis patients. International Journal of Rehabilitation Research, 30(1), 81-85.

Kurtzke, J. F. (1983). Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology, 33(11), 1444-1452. https://doi.org/10.1212/wnl.33.11.1444

Learmonth, Y. C., Paul, L., Miller, L., Mattison, P., & McFadyen, A. K. (2012). The effects of a 12-week leisure centre-based, group exercise intervention for people moderately affected with multiple sclerosis: a randomized controlled pilot study. Clinical rehabilitation, 26(7), 579-593.‏ https://doi.org/10.1177/0269215511423946

Lewandowski, W., & Jacobson, A. (2013). Bridging the gap between mind and body: a biobehavioral model of the effects of guided imagery on pain, pain disability, and depression. Pain Management Nursing, 14(4), 368-378. https://doi.org/10.1016/j.pmn.2011.08.001

National Institute of Mental Health (2024). Depression. https://www.nimh.nih.gov/health/topics/depression

Marrie, R. A., Horwitz, R., Cutter, G., & Tyry, T. (2012). Cumulative impact of comorbidity on quality of life in MS. Acta neurologica Scandinavica, 125(3), 180-186. https://doi.org/10.1111/j.1600-0404.2011.01526.x

Marrie, R.A., Walld, R., Bolton., J.M., et al. (2017). Estimating annual prevalence of depression and anxiety disorder in multiple sclerosis using administrative data. BMC research notes, 10(1): 619. https://doi.org/10.1186/s13104-017-2958-1

Marrie, R. A., Zhang, L., Lix, L. M., Graff, L. A., Walker, J. R., Fisk, J. D., ... & Bernstein, C. N. (2018). The validity and reliability of screening measures for depression and anxiety disorders in multiple sclerosis. Multiple sclerosis and related disorders, 20, 9-15. https://doi.org/10.1016/j.msard.2017.12.007

Menzies, V., Lyon, D. E., Elswick, R. K., McCain, N. L., & Gray, D. P. (2014). Effects of guided imagery on biobehavioral factors in women with fibromyalgia. Journal of behavioral medicine, 37, 70-80. https://doi.org/10.1007/s10865-012-9464-7

Motl, R. W., Sandroff, B. M., Suh, Y., & Sosnoff, J. J. (2012). Energy cost of walking and its association with gait parameters, daily activity, and fatigue in persons with mild multiple sclerosis. Neurorehabilitation and neural repair, 26(8), 1015-1021. https://doi.org/10.1177/1545968312437943

Oken BS, Kishiyama S, Zajdel D, et al. (2004). Randomized controlled trial of yoga and exercise in multiple sclerosis. Neurology, 62(11), 2058–2064. https://doi.org/10.1212/01.wnl.0000129534.88602.5c

Petajan, J. H., Gappmaier, E., White, A. T., Spencer, M. K., Mino, L., & Hicks, R. W. (1996). Impact of aerobic training on fitness and quality of life in multiple sclerosis. Annals of neurology, 39(4), 432-441. https://doi.org/10.1002/ana.410390405

Pedersen, B. K. (2019). Physical activity and muscle–brain crosstalk. Nature Reviews Endocrinology, 15(7), 383-392. https://doi.org/10.1038/s41574-019-0174-x

Ploughman, M., Wallack, E. M., Chatterjee, T., Kirkland, M. C., Curtis, M. E., Lifestyle, T. H., & Aging with MS Consortium. (2020). Under-treated depression negatively impacts lifestyle behaviors, participation and health-related quality of life among older people with multiple sclerosis. Multiple Sclerosis and Related Disorders, 40, 101919. https://doi.org/10.1016/j.msard.2019.101919

Pokryszko-Dragan, A., Frydecka, I., Kosmaczewska, A., Ciszak, L., Bilińska, M., Gruszka, E., ... & Frydecka, D. (2012). Stimulated peripheral production of interferon-gamma is related to fatigue and depression in multiple sclerosis. Clinical neurology and neurosurgery, 114(8), 1153-1158. https://doi.org/10.1016/j.clineuro.2012.02.048

Robertson, I. H., Ward, T., Ridgeway, V., & Nimmo-Smith, I. A. N. (1996). The structure of normal human attention: The Test of Everyday Attention. Journal of the International Neuropsychological society, 2(6), 525-534. https://doi.org/10.1017/s1355617700001697

Rossi, S., Studer, V., Motta, C., Polidoro, S., Perugini, J., Macchiarulo, G., ... & Centonze, D. (2017). Neuroinflammation drives anxiety and depression in relapsing-remitting multiple sclerosis. Neurology, 89(13), 1338-1347. https://doi.org/10.1212/WNL.0000000000004411

Rosti, E., Hämäläinen, P., Koivisto, K., & Hokkanen, L. (2006). The PASAT performance among patients with multiple sclerosis: analyses of responding patterns using different scoring methods. Multiple Sclerosis Journal, 12(5), 586-593. https://doi.org/10.1177/1352458506070624

Salmon, P. (2001). Effects of physical exercise on anxiety, depression, and sensitivity to stress: a unifying theory. Clinical psychology review, 21(1), 33-61. https://doi.org/10.1016/s0272-7358(99)00032-x

Sandry, J., Akbar, N., Zuppichini, M., DeLuca, J., & Sun, M. K. (2016). Cognitive rehabilitation in multiple sclerosis. Research progress in Alzheimer’s disease and Dementia, 6, 195-233.

Schmidt, S. & Wonneberger, M. (2014). Long-term endurance exercise improves aerobic capacity in patients with relapsing–remitting Multiple Sclerosis: Impact of baseline fatigue. Journal of the neurological sciences, 336(1-2), 29-35. https://doi.org/10.1016/j.jns.2013.09.035

Schulz, K. H., Gold, S. M., Witte, J., Bartsch, K., Lang, U. E., Hellweg, R., ... & Heesen, C. (2004). Impact of aerobic training on immune-endocrine parameters, neurotrophic factors, quality of life and coordinative function in multiple sclerosis. Journal of the neurological sciences, 225(1-2), 11-18. https://doi.org/10.1016/j.jns.2004.06.009

Solaro, C., Gamberini, G., & Masuccio, F. G. (2018). Depression in multiple sclerosis: epidemiology, aetiology, diagnosis and treatment. CNS drugs, 32(2), 117-133.‏ https://doi.org/10.1007/s40263-018-0489-5

Surakka, J., Romberg, A., Ruutiainen, J., Aunola, S., Virtanen, A., Karppi, S. L., & Mäentaka, K. (2004). Effects of aerobic and strength exercise on motor fatigue in men and women with multiple sclerosis: a randomized controlled trial. Clinical rehabilitation, 18(7), 737-746. https://doi.org/10.1191/0269215504cr780oa

Swank, C., Thompson, M., & Medley, A. (2013). Aerobic exercise in people with multiple sclerosis: its feasibility and secondary benefits. International journal of MS care, 15(3), 138-145.‏ https://doi.org/10.7224/1537-2073.2012-037

Tarasiuk, J., Kapica-Topczewska, K., Czarnowska, A., Chorąży, M., Kochanowicz, J., & Kułakowska, A. (2022). Co-occurrence of fatigue and depression in people with multiple sclerosis: a mini-review. Frontiers in Neurology, 12, 817256. https://doi.org/10.3389/fneur.2021.817256

Thompson, A. J., Banwell, B. L., Barkhof, F., Carroll, W. M., Coetzee, T., Comi, G., ... & Cohen, J. A. (2018). Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria. The Lancet Neurology, 17(2), 162-173. https://doi.org/10.1016/s1474-4422(17)30470-2

Tombaugh, N. T. (2006). Comprehensive review of the Paced Auditory Serial Addition Test (PASAT). Archives of Clinical Neuropsychology, 21(1), 53–76. https://doi.org/10.1016/j.acn.2005.07.006

Walker, L. A. S., Berard, J. A., Berrigan, L. I., Rees, L. M., & Freedman, M. S. (2012). Detecting cognitive fatigue in multiple sclerosis: method matters. Journal of the neurological sciences, 316(1-2), 86-92. https://doi.org/10.1016/j.jns.2012.01.021

West, J. (1985). An Arabic validation of a depression inventory. International Journal of Social Psychiatry, 31(4), 282-289. https://doi.org/10.1177/002076408503100406

White, A. J., & Russell, F. (2008). Symptomatic management and rehabilitation in Multiple Sclerosis. Journal of Neurology, Neurosurgery and Psychiatry, 71(Suppl 2), 22-27.

Zhang, W., Chang, L., Zhang, C., Zhang, R., Li, Z., Chai, B., ... & Mulholland, M. (2015). Irisin: a myokine with locomotor activity. Neuroscience letters, 595, 7-11. https://doi.org/10.1016/j.neulet.2015.03.069

Zigmond, A. S., & Snaith, R. P. (1983). The hospital anxiety and depression scale. Acta psychiatrica scandinavica, 67(6), 361-370. https://doi.org/10.1111/j.1600-0447.1983.tb09716.x

Published
12-11-2023
How to Cite
Abd-ElRaheem , H. Z., Elwishy , A. A., Shehata , H. S. M., & Awad , A. (2023). Comparing the effect of aerobic exercises and guided imagery on depression in patients with multiple sclerosis. SPORT TK-EuroAmerican Journal of Sport Sciences, 12, 19. https://doi.org/10.6018/sportk.554281
Issue
Section
Articles