The effect of whole-body vibration training on selected breast cancer risk factors in obese postmenopausal women: A randomized controlled trial
Resumen
Menopause is associated with various hormonal changes leading to many complications such as obesity, hot flashes and increased liability for breast cancer, that intractably alter female quality of life. This study was conducted to determine the effect of whole-body vibration training (WBVT) on body mass index and serum prolactin concentration, as risk factors for breast cancer and severity of hot flashes in obese postmenopausal women. A prospective, randomized, parallel group, active controlled study with a 1:1 allocation ratio was carried out. A total of 40 obese postmenopausal women (aged 50 to 60 years, postmenopausal for at least 3 years, with a body mass index BMI between 30-39.9 kg/m2) were randomly assigned into two equal groups (group A and B). Group A (WBVT, n = 20) received WBVT, 3 sessions per week for 3 months, while group B (control group, n = 20) was asked to retrain their usual lifestyle pattern. They were all instructed about healthy dieting. Statistical analysis was performed utilizing SPSS for windows, version 18 (SPSS, Inc., Chicago, IL). The results of our study showed that there was a statistically significant reduction in all measured variables in group A in post-study (p < 0.05), while the control group (B) showed a non-statistically significant decrease in these variables in comparison to the pre-study (p > 0.05). Comparison of the two groups after treatment showed a statistically significant decrease in the measured variables, in favor of the study group A (p < 0.05). From the obtained results, it was concluded that whole body vibration is effective in decreasing BMI and waist circumference, in addition to reducing serum prolactin concentration and the severity of hot flashes in obese postmenopausal women. Therefore, it could be used to decrease the risk of breast cancer in obese postmenopausal women.
Descargas
Citas
Bellia, A., Sallì, M., Lombardo, M., D’Adamo, M., Guglielmi, V., Tirabasso, C., Giordani, L. …& Sbraccia, P. (2014). Effects of whole-body vibration plus diet on insulin-resistance in middle-aged obese subjects. International Journal of Sports Medicine, 35(6), 511–516. https://doi.org/10.1055/s-0033-1354358
Bergström, A., Pisani, P., Tenet, V., Wolk, A., & Adami, H.O. (2001). Overweight as an avoidable cause of cancer in Europe. International Journal of Cancer, 91(3), 421-30.
Carver, K. C., Arendt, L. M., & Schuler, L. A. (2009). Complex prolactin crosstalk in breast cancer: new therapeutic implications. Molecular and Cellular Endocrinology, 307(1-2),1-7.
Emara, H. M., Mohamed, M. A., El-Nahas, E. M., & Hussien H. E. (2013). Effect of Aerobic Exercise on Depression and Insomnia in Post-Menopausal Women. British Journal of Applied Science & Technology, 3(3), 557.
Figueroa, A., Kalfon, R., & Wong, A. (2015). Whole-body vibration training decreases ankle systolic blood pressure and leg arterial stiffness in obese postmenopausal women with high blood pressure. Menopause, 22(4), 423-7. https://doi.org/10.1097/GME.0000000000000332
Fratini, A., Bonci, T., & Bull, A. M. (2016). Whole body vibration treatments in postmenopausal women can improve bone mineral density: results of a stimulus focussed meta-analysis. PLoS One, 11(12), e0166774. https://doi.org/10.1371/journal.pone.0166774
Gokce, N., Keaney, J. F., Hunter, L. M., Watkins, M. T., Nedeljkovic, Z. S., Menzoian, J. O., & Vita, J. A. (2003). Predictive value of noninvasively determined endothelial dysfunction for long-term cardiovascular events in patients with peripheral vascular disease. Journal of the American College of Cardiology, 41(10), 1769-75. https://doi.org/10.1016/s0735-1097(03)00333-4
Gonzalez-Iglesias, A. E., Murano, T., Li, S., Tomić, M., & Stojilkovic, S. S. (2008). Dopamine inhibits basal prolactin release in pituitary lactotrophs through pertussis toxin-sensitive and-insensitive signaling pathways. Endocrinology, 149(4), 1470-9. https://doi.org/10.1210/en.2007-0980
Hackney, A. C. & Saeidi A. (2019). Thyroid Axis, Prolactin, and Exercise in Humans. Current Opinion in Endocrine and Metabolic Research, 9, 45–50. https://doi.org/10.1016/j.coemr.2019.06.012
Harvey, P. J., Morris, B. L., Kubo, T., Picton, P. E., Su, W. S., Notarius, C. F., & Floras, J. S. (2005). Hemodynamic after-effects of acute dynamic exercise in sedentary normotensive postmenopausal women. Journal of Hypertension, 23(2), 285-292. https://doi.org/10.1097/00004872-200502000-00010
Hoehn, K., & Marieb, E. (2007). Human anatomy and physiology. Pearson Benjamin Cummings.
Ibrahim, Z. M., Sayed, W. A., & El-Hamid, S. A. (2015). Prevalence of menopausal related symptoms and their impact on quality of life among Egyptian women. Clinical and Experimental Obstetrics and Gynecology, 42(2), 161-7.
Key, T., Appleby, P., Reeves, G., Roddam, A., Dorgan, J., & Longcope, C. (2003). Body mass index, serum sex hormones and breast cancer risk in postmenopausal women. Journal of the National Cancer Institute, 95(16), 1218–1226. https://doi.org/10.1093/jnci/djg022
Kraemer, R. R., Johnson, L. G., Haltom, R., Kraemer, G. R., Gaines, H., Drapcho, M., Gimple, T., & Castracane, V. D. (1998). Effects of hormone replacement on growth hormone and prolactin exercise responses in postmenopausal women. Journal of Applied Physiology, 84(2), 703-708. https://doi.org/10.1152/jappl.1998.84.2.703
Lee, S. W., Mancuso, C. A., & Charlson, M. E. (2003). Expectations and outcomes associated with new practice of energy-yoga: Qualitative study. Journal of Clinical Epidemiology, 56(9), 922.
MacLennan, A. H. (2009). Evidence‐based review of therapies at the menopause. International Journal of Evidence‐Based Healthcare, 7(2), 112-123. https://doi.org/10.1111/j.1744-1609.2009.00133.x
Mancini, T., Casanueva, F. F., & Giustina, A. (2008). Hyperprolactinemia and prolactinomas. Endocrinology and Metabolism Clinics of North America, 37(1), 67-99. https://doi.org/10.1016/j.ecl.2007.10.013
Martí, O., & Armario, A. (1998). Anterior pituitary response to stress: time-related changes and adaptation. International Journal of Developmental Neuroscience, 16(3-4), 241-260. https://doi.org/10.1016/s0736-5748(98)00030-6
Mastorakos, G., Pavlatou, M., Diamanti-Kandarakis, E., Chrousos, G. P. (2005). Exercise and the stress system. Hormones (Athens), 4(2), 73-89.
Melo, F. A. T. D., Melo, G. F. D., Albuquerque Neto, S. L. D., Silva, R. W. D., Franca, N. M. D., Silva, A. A. D., & Ferreira, C. E. S. (2019). Whole-body vibration training protocols in obese individuals: a systematic review. Revista Brasileira de Medicina do Esporte, 25(6), 527-533.
Merriman, H., & Jackson, K. (2009). The effects of whole-body vibration training in aging adults: a systematic review. Journal of Geriatric Physical Therapy, 32(3), 134-145. https://doi.org/10.1519/00139143-200932030-00009
Mohamed, M., Mohamed, G., & Abou-Louz, S. (2015). Effect of aerobic exercise assisted with soy products on hot flushes and quality of life in postmenopausal women. Bulletin of Faculty of Physical Therapy, 20, 1-9.
Paineiras-Domingos, L. L., Sá-Caputo, D. D. C. D., Moreira-Marconi, E., Morel, D. S., da Fontoura Dionello, C., Sousa-Gonçalves, C. R., ... & Bernardo-Filho, M. (2017). Can whole body vibration exercises affect growth hormone concentration? A systematic review. Growth Factors, 35(4-5), 189-200.
Randolph J, J. F., Sowers, M., Bondarenko, I., Gold, E. B., Greendale, G. A., Bromberger, J. T., Brockwell, S. E., & Matthews, K. A. (2005). The relationship of longitudinal change in reproductive hormones and vasomotor symptoms during the menopausal transition. The Journal of Clinical Endocrinology & Metabolism, 90(11), 6106-12.
Santos‐Silva, C. M., Barbosa, F. R., Lima, G. A., Warszawski, L., Fontes, R., Domingues, R. C., & Gadelha, M. R. (2011). BMI and metabolic profile in patients with prolactinoma before and after treatment with dopamine agonists. Obesity, 19(4), 800-805. https://doi.org/10.1038/oby.2010.150
Shechter, M., Issachar, A., Marai, I., Koren-Morag, N., Freinark, D., Shahar, Y., Shechter, A., & Feinberg, M. S. (2009). Long-term association of brachial artery flow-mediated vasodilation and cardiovascular events in middle-aged subjects with no apparent heart disease. International Journal of Cardiology, 134(1), 52-58.
Shi, R., Yu, H., McLarty, J., & Glass, J. (2004). IGF‐I and breast cancer: a meta‐analysis. International Journal of Cancer, 111(3), 418-423. https://doi.org/10.1002/ijc.20233
Steinmetz, R., Brown, N. G., Allen, D. L., Bigsby, R. M., & Ben-Jonathan, N. (1997). The environmental estrogen bisphenol A stimulates prolactin release in vitro and in vivo. Endocrinology, 138(5), 1780-1786. https://doi.org/10.1210/endo.138.5.5132
Stojanovska, L., Apostolopoulos, V., Polman, R., & Borkoles, E. (2014). To exercise, or, not to exercise, during menopause and beyond. Maturitas, 77(4), 318-323. https://doi.org/10.1016/j.maturitas.2014.01.006
Tamini, S., De Micheli, R., Tringali, G., Bernardo-Filho, M., & Sartorio, A. (2020). Acute Effects of Whole-Body Vibration Exercises at 2 Different Frequencies Versus an Aerobic Exercise on Some Cardiovascular, Neuromotor and Musculoskeletal Parameters in Adult Patients with Obesity. Dose-Response, 18(4), 1559325820965005. https://doi.org/10.1177/1559325820965005
Tartibian, B., Sharabiyani, S., & Abbasi, A. S. (2009). Effect of regular aerobic exercise on vasomotor symptoms (hot flashes) in postmenopausal women. Journal of Babol University of Medical Sciences, 11(4), 36-41.
Thapa, S. & Bhusal, K. (2022). Hyperprolactinemia. StatPearls Publishing.
Vissers, D., Verrijken, A., Mertens, I., Van Gils, C., Van de Sompel, A., Truijen, S., Van Gaal, L. (2010). Effect of long-term whole body vibration training on visceral adipose tissue: a preliminary report. Obesity Facts, 3(2), 93-100. https://doi.org/10.1159/000301785
Zago, M., Capodaglio, P., Ferrario, C., Tarabini, M., & Galli, M. (2018). Whole-body vibration training in obese subjects: A systematic review. PLoS One, 13(9), e0202866. https://doi.org/10.1371/journal.pone.0202866
Las obras que se publican en esta revista están sujetas a los siguientes términos:
1. El Servicio de Publicaciones de la Universidad de Murcia (la editorial) conserva los derechos patrimoniales (copyright) de las obras publicadas, y favorece y permite la reutilización de las mismas bajo la licencia de uso indicada en el punto 2.
© Servicio de Publicaciones, Universidad de Murcia, 2013
2. Las obras se publican en la edición electrónica de la revista bajo una licencia Creative Commons Reconocimiento-NoComercial-SinObraDerivada 3.0 España (texto legal). Se pueden copiar, usar, difundir, transmitir y exponer públicamente, siempre que: i) se cite la autoría y la fuente original de su publicación (revista, editorial y URL de la obra); ii) no se usen para fines comerciales; iii) se mencione la existencia y especificaciones de esta licencia de uso.
3. Condiciones de auto-archivo. Se permite y se anima a los autores a difundir electrónicamente las versiones pre-print (versión antes de ser evaluada) y/o post-print (versión evaluada y aceptada para su publicación) de sus obras antes de su publicación, ya que favorece su circulación y difusión más temprana y con ello un posible aumento en su citación y alcance entre la comunidad académica.
