Ultrasonic transdermal insulin therapy: a strategy to improve wound healing and support physical performance in diabetic patients

Authors

  • Dalia G El Sayed Department of Physical Therapy for Surgery, Faculty of Physical Therapy, Modern University for Technology and Information, Egypt
  • Mohamed Salah El-Sayed Department of Physical Therapy, Faculty of Allied Medical Sciences, Al-Ahliyya Amman University, Jordan / Department of Physical Therapy for Pediatrics, Faculty of Physical Therapy, Horus University-Egypt, New Damietta, Egypt
  • Radwa F. Hammam Basic Science Department, Faculty of Physical Therapy, Modern University for Technology and Information, Egypt
  • Shimaa G. El Sayed Department of Physical Therapy for Surgery and Women’s Health, Faculty of Physical Therapy, Sinai University, Egypt
  • Amera S. Aly Department of Physical Therapy for Internal Medicine and Geriatrics, Faculty of Physical Therapy, Alsalam University, Egypt
  • Heba E. Mahmoud Department of Physical therapy for Women’s health, Faculty of Physical Therapy, Sinai University, Egypt
  • Esraa H. Rostom Department of Physical Therapy for Surgery, Faculty of Physical Therapy, Cairo University, Egypt
DOI: https://doi.org/10.6018/sportk.721751
Keywords: Transdermal Insulin, Ultrasonic, Wound Healing, Physical Performance, Diabetic Patients

Abstract

The aim of this study was to establish the impact of Transdermal Insulin Therapy in patients with chronic diabetic wound. This double blinded randomized control trial study involved 40 (12 female and 28 male) patients with stage II-III of chronic diabetic foot wound. The patients in the intervention group (I) were subjected, besides Transdermal Insulin Therapy, to Hyperpolarized light therapy and Standard wound cleaning and dressing. Hyperpolarized light therapy and Standard wound cleaning and dressing (standard treatment) were the treatment that were used in the control group (C). All patients were assessed before treatment initiation and then weekly for four consecutive weeks. Post-treatment revealed significant reductions in DIMST score IV (MD=-2.9, effect size=0.79) and DIMST score V (MD=-2.95, effect size=0.81) of the study group in comparison to the control group (p<0.01). Comparing within groups, in the intervention group there was a substantial reduction in score V in comparison with score I, II, III and IV (p<0.001), a substantial reduction in score IV in comparison with score I, II and III (p<0.001), a substantial reduction in score III in comparison with score I and II (p<0.001) and a substantial reduction in score II in comparison with score I (p<0.001). The Transdermal Insulin Therapy by ultrasound has a significant effect on wound healing and supports the physical performance of chronic diabetic foot wound patients, and it should be considered in future treatment plans for diabetic wounds.

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References

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Published
18-06-2026
How to Cite
El Sayed, D. G., El-Sayed, M. S., Hammam, R. F., El Sayed, S. G., Aly, A. S., Mahmoud, H. E., & Rostom, E. H. (2026). Ultrasonic transdermal insulin therapy: a strategy to improve wound healing and support physical performance in diabetic patients. SPORT TK-EuroAmerican Journal of Sport Sciences, 15, 53. https://doi.org/10.6018/sportk.721751
Issue
Vol. 15 (2026)
Section
Articles

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The works and papers that are published in this Journal are subject to the following terms:

1. The Publication Service of the University of Murcia (the publisher) has the Publication Rights (Copyright) to the published papers and works, and favors and permits the reusing of the same under the license indicated in point 2.

© Servicio de Publicaciones, Universidad de Murcia, 2013

2. The papers and works are to be published in the digital edition of the Journal under the license Creative Commons Reconocimiento-No Comercial-Sin Obra Derivada 3.0 España (legal text). The copying, using, spreading, transmitting and publicly displaying of the papers, works or publication are permitted as long as: i) the authors and original sources (Journal, publisher and URL of the publication) are quoted; ii) it is not used for commercial benefit; iii) the existence and specifications of this users license are mentioned.

3. Conditions of Self-Archiving. It is permitted and encouraged that the authors spread electronically the pre-print (before printing) and/or post-print (the revised, evaluated and accepted) versions of their papers or works before their publication since this favors their circulation and early diffusion and therefore can help increase their citation and quotation, and also there reach through the academic community.