Effect of combined high-intensity interval training and inspiratory muscle training on pulmonary function and exercise capacity in COPD patients

Authors

  • Fahad H. Alahmadi Respiratory Therapy Department, College of Medical Rehabilitation Sciences, Taibah University, Madinah, Saudi Arabia.
  • Ahmed S. Ahmed Department of Physical Therapy for Cardiovascular, Respiratory Disorders, and Geriatrics, Faculty of Physical Therapy, Cairo University, Giza, Egypt / Department of Physical Therapy and Health Rehabilitation, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia.
  • Saud M. Alrawaili Department of Physical Therapy and Health Rehabilitation, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia.
  • Samah M. Ismail Respiratory Therapy Department, College of Medical Rehabilitation Sciences, Taibah University, Madinah, Saudi Arabia / Department of Physical Therapy for Cardiovascular, Respiratory Disorders, and Geriatrics, Faculty of Physical Therapy, Cairo University, Giza, Egypt.
DOI: https://doi.org/10.6018/sportk.679611
Keywords: COPD, HIIT, IMT, Exercise, Pulmonary Function

Abstract

The aim of this study was to investigate the effect of combined high intensity interval training (HIIT) and inspiratory muscle training (IMT) on pulmonary function and exercise capacity in patients COPD. This randomized, controlled trial study involved 100 COPD patients (GOLD stages II and III) aged between 40 and 70 years. Subjects were randomly assigned to one of two groups. The study group (n=50) underwent 8 weeks combined HIIT and IMT. The HIIT protocol involved four intervals, each lasting 4 minutes, beginning at 70% of maximum power and building to a target intensity of at least 85% HRmax. The IMT sessions included 2-3 sets of 30 breaths (totaling 60-90 breaths per session), with a two-minute rest between sets, three days per week starting with 30% of PImax and reaching 60% of PImax. The control group (n=50) performed an 8-week program of therapeutic education and 30-min self-based cycling or walking. Pulmonary function tests, incremental cycle ergometer tests, 6 min walk tests and inspiratory muscle strength were performed, and dyspnea and Halth-Related Quality of Life (HRQoL) were assessed before and after the intervention period. Results indicated that combined HIIT and IMT significantly improved exercise capacity, respiratory muscle strength, dyspnea, and quality of life in patients with COPD (p<0.05). There were no significant changes in pulmonary functions (p>0.05). This study suggests that integrating HIIT with IMT can effectively enhance the overall prognosis of patients with COPD.

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References

Aakerøy, L., Nørstebø, E. A., Thomas, K. M., Holte, E., Hegbom, K., Brønstad, E., & Steinshamn, S. (2021). High-intensity interval training and pulmonary hemodynamics in COPD with hypoxemia. European Clinical Respiratory Journal, 8(1), 1-12. https://doi.org/10.1080/20018525.2021.1984642

Abedi Yekta, A. H., Poursaeid Esfahani, M., Salehi, S., Hassabi, M., Khosravi, S., Kharabian, S., Sohrabi, M. R., Mafi, A. A., & Rezaei, S. (2019). Assessment of the Effects of Inspiratory Muscle Training (IMT) and Aerobic Training on the Quality of Life of Patients with Chronic Obstructive Pulmonary Disease. Tanaffos, 18(3), 223–229.

Alexiou, C., Ward, L., Hume, E., Armstrong, M., Wilkinson, M., & Vogiatzis, I. (2021). Effect of interval compared to continuous exercise training on physiological responses in patients with chronic respiratory diseases: A systematic review and meta-analysis. Chronic Respiratory Disease, 18, 1–15. https://doi.org/10.1177/14799731211029663

Al-Rawaf, H. A., Gabr, S. A., Iqbal, A., & Alghadir, A. H. (2023). High-intensity interval training improves glycemic control, cellular apoptosis, and oxidative stress of type 2 diabetic patients. Medicina,, 59(7), 1-16. https://doi.org/10.3390/medicina59071282

American Thoracic Society. (2002). ATS statement: Guidelines for the six-minute walk test. American Journal of Respiratory and Critical Care Medicine, 166(1), 111–117.

Ammous, O., Feki, W., Lotfi, T., Khamis, A. M., Gosselink, R., Rebai, A., & Kammoun, S. (2023). Inspiratory muscle training, with or without concomitant pulmonary rehabilitation, for chronic obstructive pulmonary disease (COPD). Cochrane Database of Systematic Reviews, 2023(1), 1-62. https://doi.org/10.1002/14651858.CD013778.pub2

Arnardóttir, R. H., Boman, G., Larsson, K., Hedenström, H., & Emtner, M. (2007). Interval training compared with continuous training in patients with COPD. Respiratory Medicine, 101(6), 1196–1204. https://doi.org/10.1016/j.rmed.2006.10.005

Battaglia, E., Fulgenzi, A., & Ferrero, M. E. (2009). Rationale of the combined use of inspiratory and expiratory devices in improving maximal inspiratory pressure and maximal expiratory pressure of patients with chronic obstructive pulmonary disease. Archives of Physical Medicine and Rehabilitation, 90(6), 913–918. https://doi.org/10.1016/j.apmr.2008.11.019

Beauchamp, M. K., Nonoyama, M., Goldstein, R. S., Hill, K., Dolmage, T. E., Mathur, S., et al. (2010). Interval versus continuous training in individuals with chronic obstructive pulmonary disease: A systematic review. Thorax, 65(2), 157–164. https://doi.org/10.1136/thx.2009.123257

Beaumont, M., Forget, P., Couturaud, F., & Reychler, G. (2018). Effects of inspiratory muscle training in COPD patients: A systematic review and meta-analysis. The Clinical Respiratory Journal, 12(6), 2178–2188. https://doi.org/10.1111/crj.12783

Beaumont, M., Mialon, P., Ber-Moy, C., Lochon, C., Péran, L., Pichon, R., et al. (2015). Inspiratory muscle training during pulmonary rehabilitation in chronic obstructive pulmonary disease. Chronic Respiratory Disease, 12(4), 305–312. https://doi.org/10.1177/1479972315593839

Bolton, C. E., Bevan-Smith, E. F., Blakey, J. D., Crowe, P., Elkin, S. L., Garrod, R., et al. (2013). British Thoracic Society guideline on pulmonary rehabilitation in adults: Accredited by NICE. Thorax, 68, 1–30. https://doi.org/10.1136/thoraxjnl-2013-203808

Borg, G. A. (1982). Psychophysical bases of perceived exertion. Medicine & Science in Sports & Exercise, 14(5), 377–381.

Brønstad, E., Tjønna, A. E., Rognmo, Ø., Dalen, H., Heggli, A. M., Wisløff, U., et al. (2013). Aerobic exercise training improves right- and left ventricular systolic function in patients with COPD. Journal of Chronic Obstructive Pulmonary Disease, 10(3), 300–306. https://doi.org/10.3109/15412555.2012.744884

Buran Cirak, Y., Yilmaz Yelvar, G. D., & Durustkan Elbasi, N. (2022). Effectiveness of 12-week inspiratory muscle training with manual therapy in patients with COPD: A randomized controlled study. Clinical Respiratory Journal, 16(4), 317–328. https://doi.org/10.1111/crj.13458

Casaburi, R., & Zuwallack, R. (2009). Pulmonary rehabilitation for management of chronic obstructive pulmonary disease. Clinical Therapeutics, 31(5), 770–784. https://doi.org/10.1016/j.clinthera.2009.05.002

Charususin, N., Gosselink, R., Decramer, M., McConnell, A., Saey, D., Maltais, F., Derom, E., Vermeersch, S., van Helvoort, H., Heijdra, Y., Klaassen, M., Glöckl, R., Kenn, K., & Langer, D. (2013). Inspiratory muscle training protocol for patients with chronic obstructive pulmonary disease (IMTCO study): A multicentre randomised controlled trial. BMJ Open, 3(8), 1-7. https://doi.org/10.1136/bmjopen-2013-003101

Chen, D., Curtis, J. L., & Chen, Y. (2023). Twenty years of changes in the definition of early chronic obstructive pulmonary disease. Chinese Medical Journal Pulmonary and Critical Care Medicine, 1(2), 84–93. https://doi.org/10.1016/j.pccm.2023.03.004

Chuang, H. Y., Chang, H. Y., Fang, Y. Y., & Guo, S. E. (2017). The effects of threshold inspiratory muscle training in patients with chronic obstructive pulmonary disease: A randomised experimental study. Journal of Clinical Nursing, 26(23–24), 4830–4838. https://doi.org/10.1111/jocn.13805

Coppoolse, R., Schols, A., Baarends, E., Mostert, R., Akkermans, M., Janssen, P., et al. (1999). Interval versus continuous training in patients with severe COPD: A randomized clinical trial. European Respiratory Journal, 14, 258–263.

Cotes, J. E., Chinn, D. J., Quanjer, P. H., Roca, J., & Yernault, J. C. (1993). Standardization of the measurement of transfer factor (diffusing capacity). European Respiratory Journal, 6, 41–52.

De Brandt, J., Spruit, M. A., Derave, W., Hansen, D., Vanfleteren, L. E. G. W., & Burtin, C. (2016). Changes in structural and metabolic muscle characteristics following exercise-based interventions in patients with COPD: A systematic review. Expert Review of Respiratory Medicine, 10(5), 521–545. https://doi.org/10.1586/17476348.2016.1174575

Evans, J. A., & Whitelaw, W. A. (2009). The assessment of maximal respiratory mouth pressures in adults. Respiratory Care, 54(10), 1348–1359.

Figueiredo, R. I. N., Azambuja, A. M., Cureau, F. V., & Sbruzzi, G. (2020). Inspiratory muscle training in COPD. Respiratory Care, 65(8), 1189–1201. https://doi.org/10.4187/respcare.07273

Gao, M., Huang, Y., Wang, Q., Liu, K., & Sun, G. (2022). Effects of high-intensity interval training on pulmonary function and exercise capacity in individuals with chronic obstructive pulmonary disease: A meta-analysis and systematic review. Advances in Therapy, 39, 94–116. https://doi.org/10.1007/s12325-021-01938-5

Gosselink, R., De Vos, J., Van Den Heuvel, S. P., Segers, J., Decramer, M., & Kwakkel, G. (2011). Impact of inspiratory muscle training in patients with COPD: What is the evidence? European Respiratory Journal, 37, 416–425. https://doi.org/10.1183/09031936.00031810

Gouzi, F., Préfaut, C., Abdellaoui, A., Roudier, E., De Rigal, P., Molinari, N., et al. (2013). Blunted muscle angiogenic training response in COPD patients versus sedentary controls. European Respiratory Journal, 41(4), 806–814. https://doi.org/10.1183/09031936.00095312

Graham, B. L., Brusasco, V., Burgos, F., Cooper, B. G., Jensen, R., Kendrick, A., MacIntyre, N. R., Thompson, B. R., & Wanger, J. (2017). 2017 ERS/ATS standards for single-breath carbon monoxide uptake in the lung. European Respiratory Journal, 49(1), 1-31. https://doi.org/10.1183/13993003.00016-2016

Graham, B. L., Steenbruggen, I., Barjaktarevic, I. Z., Cooper, B. G., Hall, G. L., Hallstrand, T. S., et al. (2019). Standardization of spirometry 2019 update: An official American Thoracic Society and European Respiratory Society technical statement. American Journal of Respiratory and Critical Care Medicine, 200(8), 70–88. https://doi.org/10.1164/rccm.201908-1590ST

Hamilton, D. M., & Haennel, R. G. (2000). Validity and reliability of the 6-minute walk test in a cardiac rehabilitation population. Journal of Cardiopulmonary Rehabilitation, 20(3), 156–164.

Han, B., Chen, Z., Ruan, B., Chen, Y., Lv, Y., Li, C., & Yu, L. (2024). Effects of inspiratory muscle training in people with chronic obstructive pulmonary disease: A systematic review and meta-analysis. Life, 14(1), 1-17. https://doi.org/10.3390/life14010112

Hill, K., Cecins, N. M., Eastwood, P. R., & Jenkins, S. C. (2010). Inspiratory muscle training for patients with chronic obstructive pulmonary disease: A practical guide for clinicians. Archives of Physical Medicine and Rehabilitation, 91(9), 1466–1470.

Hill, K., Jenkins, S. C., Philippe, D. L., Cecins, N., Shepherd, K. L., Green, D. J., Hillman, D. R., & Eastwood, P. R. (2006). High-intensity inspiratory muscle training in COPD. European Respiratory Journal, 27(6), 1119–1128. https://doi.org/10.1183/09031936.06.00009105

Huang, Z., Li, Z., Yan, M., Zheng, J., Huang, W., Hong, L., Lu, Q., Liu, L., Huang, X., Fan, H., Su, W., Huang, X., Wu, X., Guo, Z., Qiu, C., Zhao, Z., & Hong, Y. (2024). Effect of respiratory muscle training in patients with stable chronic obstructive pulmonary disease: A systematic review and meta-analysis. Heliyon, 10(7), 1-11. https://doi.org/10.1016/j.heliyon.2024.e25948

Jones, P. W. (2005). St. George’s Respiratory Questionnaire: MCID. Journal of Chronic Obstructive Pulmonary Disease, 2(1), 75–79.

Jones, P. W., Harding, G., Berry, P., Wiklund, I., Chen, W. H., & Kline Leidy, N. (2009). Development and first validation of the COPD Assessment Test. European Respiratory Journal, 34(3), 648–654. https://doi.org/10.1183/09031936.00102509

Jones, P. W., Tabberer, M., & Chen, W. H. (2011). Creating scenarios of the impact of COPD and their relationship to COPD Assessment Test (CAT™) scores. BMC Pulmonary Medicine, 11, 1-7. https://doi.org/10.1186/1471-2466-11-42

Lin, F. L., Yeh, M. L., Lai, Y. H., Lin, K. C., Yu, C. J., & Chang, J. S. (2019). Two-month breathing-based walking improves anxiety, depression, dyspnoea and quality of life in chronic obstructive pulmonary disease: A randomised controlled study. Journal of Clinical Nursing, 28(19–20), 3632–3640. https://doi.org/10.1111/jocn.14958

MacInnis, M. J., & Gibala, M. J. (2017). Physiological adaptations to interval training and the role of exercise intensity. The Journal of Physiology, 595(9), 2915–2930. https://doi.org/10.1113/JP273196

Maltais, F., Decramer, M., Casaburi, R., Barreiro, E., Burelle, Y., Debigaré, R., Dekhuijzen, P. N., Franssen, F., Gayan-Ramirez, G., Gea, J., Gosker, H. R., Gosselink, R., Hayot, M., Hussain, S. N., Janssens, W., Polkey, M. I., Roca, J., Saey, D., Schols, A. M., Spruit, M. A., ATS/ERS Ad Hoc Committee on Limb Muscle Dysfunction in COPD (2014). An official American Thoracic Society/European Respiratory Society statement: update on limb muscle dysfunction in chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine, 189(9), 15–62. https://doi.org/10.1164/rccm.201402-0373ST

Marchand, E., & Decramer, M. (2000). Respiratory muscle function and drive in chronic obstructive pulmonary disease. Clinics in Chest Medicine, 21(4), 679–692. https://doi.org/10.1016/S0272-5231(05)70170-3

McCarthy, B., Casey, D., Devane, D., Murphy, K., Murphy, E., & Lacasse, Y. (2015). Pulmonary rehabilitation for chronic obstructive pulmonary disease. Cochrane Database of Systematic Reviews, 2015(2), 1-212. https://doi.org/10.1002/14651858.CD003793.pub3

Morris, N. R., Walsh, J., Adams, L., & Alison, J. A. (2016). Exercise training in COPD: What is it about intensity? Respirology, 21(7), 1185–1192. https://doi.org/10.1111/resp.12778

Mota, J. C., Santos, M. R. dos, Sousa, L. R. de, Abdoral, P. R. G., Abdoral, L. S. R., & Miranda, C. J. C. de P. (2023). Inspiratory muscle training in people with chronic obstructive pulmonary disease (COPD): A systematic review. Fisioterapia e Pesquisa, 30, 1-11. https://doi.org/10.1590/1809-2950/23033430023042023

Oga, T., Nishimura, K., Tsukino, M., Sato, S., Hajiro, T., & Mishima, M. (2005). Exercise capacity deterioration in patients with COPD: Longitudinal evaluation over 5 years. Chest, 128(1), 62–69. https://doi.org/10.1378/chest.128.1.62

Patessio, A., Carone, M., Ioli, F., & Donner, C. F. (1992). Ventilatory and metabolic changes as a result of exercise training in COPD patients. Chest, 101, 274–278. https://doi.org/10.1378/chest.101.5_Supplement.274S

Polverino, F., Laucho-Contreras, M. E., Petersen, H., Bijol, V., Sholl, L. M., Choi, M. E., et al. (2017). A pilot study linking endothelial injury in lungs and kidneys in chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine, 195(11), 1464–1476. https://doi.org/10.1164/rccm.201604-0759OC

Puhan, M. A., Büsching, G., Schünemann, H. J., VanOort, E., Zaugg, C., & Frey, M. (2006). Interval versus continuous high-intensity exercise in chronic obstructive pulmonary disease: A randomized trial. Annals of Internal Medicine, 145(11), 816–825. https://doi.org/10.7326/0003-4819-145-11-200612050-00006

Quanjer, P. H. (1993). Lung volumes and forced ventilatory flows: Report of working party, standardization of lung function tests, European Community for Steel and Coal—Official statement of the European Respiratory Society. European Respiratory Journal, 16, 5–40.

Ramirez-Sarmiento, A., Orozco-Levi, M., Guell, R., Barreiro, E., Hernandez, N., Mota, S., Sangenis, M., Broquetas, J. M., Casan, P., & Gea, J. (2002). Inspiratory muscle training in patients with chronic obstructive pulmonary disease: Structural adaptation and physiologic outcomes. American Journal of Respiratory and Critical Care Medicine, 166(11), 1491–1497. https://doi.org/10.1164/rccm.200201-032OC

Ross, R. M. (2003). ATS/ACCP statement on cardiopulmonary exercise testing. American Journal of Respiratory and Critical Care Medicine, 167(10), 1-14.

Rowland, T., Hagenbuch, S., Pober, D., & Garrison, A. (2008). Exercise tolerance and thermoregulatory responses during cycling in boys and men. Medicine & Science in Sports & Exercise, 40(2), 282–287. https://doi.org/10.1249/mss.0b013e31815c6e84

Sánchez Riera, H., Montemayor Rubio, T., Ortega Ruiz, F., Cejudo Ramos, P., Del Castillo Otero, D., Elias Hernandez, T., & Castillo Gomez, J. (2001). Inspiratory muscle training in patients with COPD: Effect on dyspnea, exercise performance, and quality of life. Chest, 120(3), 748–756. https://doi.org/10.1378/chest.120.3.748

Sawyer, A., Cavalheri, V., & Hill, K. (2020). Effects of high-intensity interval training on exercise capacity in people with chronic pulmonary conditions: A narrative review. BMC Sports Science, Medicine and Rehabilitation, 12, 1-10. https://doi.org/10.1186/s13102-020-00175-0

Sieck, G. C., Ferreira, L. F., Reid, M. B., & Mantilla, C. B. (2013). Mechanical properties of respiratory muscles. Comprehensive Physiology, 3(4), 1533–1567. https://doi.org/10.1002/cphy.c130008

Singer, J., Yelin, E. H., Katz, P. P., Sanchez, G., Iribarren, C., & Eisner, M. D. (2011). Respiratory and skeletal muscle strength in chronic obstructive pulmonary disease: Impact on exercise capacity and lower extremity function. Journal of Cardiopulmonary Rehabilitation and Prevention, 31(2), 111–119. https://doi.org/10.1097/HCR.0b013e3181eebf7b

Singh, S. J. (2014). Approaches to outcome assessment in pulmonary rehabilitation. Clinics in Chest Medicine, 35(2), 353–361.

Spruit, M. A., Singh, S. J., Garvey, C., ZuWallack, R., Nici, L., & Rochester, C. (2013). An official American Thoracic Society/European Respiratory Society statement: Key concepts and advances in pulmonary rehabilitation. American Journal of Respiratory and Critical Care Medicine, 188(8), 13–64. https://doi.org/10.1164/rccm.201309-1634ST

Vogelmeier, C. F., Criner, G. J., Martinez, F. J., Anzueto, A., Barnes, P. J., Bourbeau, J., Celli, B. R., Chen, R., Decramer, M., Fabbri, L. M., Frith, P., Halpin, D. M., López Varela, M. V., Nishimura, M., Roche, N., Rodriguez-Roisin, R., Sin, D. D., Singh, D., Stockley, R., Vestbo, J., … Agusti, A. (2017). Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease 2017 report. American Journal of Respiratory and Critical Care Medicine, 195(5), 557–582. https://doi.org/10.1164/rccm.201701-0218PP

Vogiatzis, I., Nanas, S., & Roussos, C. (2002). Interval training as an alternative modality to continuous exercise in patients with COPD. European Respiratory Journal, 20(1), 12–19. https://doi.org/10.1183/09031936.02.00269302

Vogiatzis, I., Simoes, D. C., Stratakos, G., Kourepini, E., Terzis, G., Manta, P., Athanasopoulos, D., Roussos, C., Wagner, P. D., & Zakynthinos, S. (2010). Effect of pulmonary rehabilitation on muscle remodelling in cachectic patients with COPD. European Respiratory Journal, 36(2), 301–310. https://doi.org/10.1183/09031936.00056509

Wang, K., Zeng, G. Q., Li, R., Luo, Y. W., Wang, M., Hu, Y. H., Xu, W. H., Zhou, L. Q., Chen, R. C., & Chen, X. (2017). Cycle ergometer and inspiratory muscle training offer modest benefit compared with cycle ergometer alone: A comprehensive assessment in stable COPD patients. International Journal of Chronic Obstructive Pulmonary Disease, 12, 2655–2668. https://doi.org/10.2147/COPD.S138704

Ward, T. J. C., Plumptre, C. D., Dolmage, T. E., Jones, A. V., Trethewey, R., Divall, P., Singh, S. J., Lindley, M. R., Steiner, M. C., & Evans, R. A. (2020). Change in V̇O2peak in response to aerobic exercise training and the relationship with exercise prescription in people with COPD: A systematic review and meta-analysis. Chest, 158(1), 131–144. https://doi.org/10.1016/j.chest.2020.01.052

Ward, T. J., Plumptre, C. D., Fraser-Pye, A. V., Dolmage, T. E., Jones, A. V., Trethewey, R., Latimer, L., Singh, S. J., Lindley, M. R., Steiner, M. C., & Evans, R. A. (2023). Understanding the effectiveness of different exercise training programme designs on V˙O₂peak in COPD: A component network meta-analysis. Thorax, 78(10), 1035–1038. https://doi.org/10.1136/thorax-2022-219827

Wasserman, K. (2012). Principles of exercise testing and interpretation: Including pathophysiology and clinical applications (5th ed.). Lippincott Williams & Wilkins.

Zou, J., Sun, T., Song, X., Liu, Y. M., Lei, F., Chen, M. M., Chen, Z., Zhang, P., Ji, Y. X., Zhang, X. J., She, Z. G., Cai, J., Luo, Y., Wang, P., & Li, H. (2022). Distributions and trends of the global burden of COPD attributable to risk factors by SDI, age, and sex from 1990 to 2019: a systematic analysis of GBD 2019 data. Respiratory Research, 23(1), 1-19. https://doi.org/10.1186/s12931-022-02011-y

Published
12-09-2025
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Alahmadi, F. H., Ahmed, A. S., Alrawaili, S. M., & Ismail, S. M. (2025). Effect of combined high-intensity interval training and inspiratory muscle training on pulmonary function and exercise capacity in COPD patients. SPORT TK-EuroAmerican Journal of Sport Sciences, 14, 80. https://doi.org/10.6018/sportk.679611
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