STUDY OF THE SOLUBILITY OF A-BISPHENOL IN DIFFERENT FOOD SIMULANTS

Authors

  • Julia Soriano Meseguer Departamento de Química Agrícola, Facultad de Química, Universidad de Murcia (España)
  • Víctor Bernal Conesa Departamento de Química Agrícola, Facultad de Química, Universidad de Murcia (España)
  • José Manuel Veiga del Baño Departamento de Química Agrícola, Facultad de Química, Universidad de Murcia (España)
  • José Oliva Departamento de Química Agrícola, Facultad de Química, Universidad de Murcia (España)
  • Miguel Motas Departamento de Toxicología, Facultad de Veterinaria, Universidad de Murcia (España)
  • Pedro Andreo-Martínez Departamento de Química Agrícola, Facultad de Química, Universidad de Murcia (España)
DOI: https://doi.org/10.6018/analesvet.673441
Keywords: Bisphenol A, Nephelometry, Food simulants, Solubility, Risk, Turbidity

Abstract

Bisphenol A (BPA) is a compound widely used in the manufacture of food contact materials (FCM), such as plastics, polycarbonates and epoxy resins. These materials are mainly used in metal containers, lids, cans and varnishes. Despite this use, because of its chemical properties, BPA can migrate from these materials into the food they are in contact with, creating an exposure risk for consumers. This exposure is of concern due to the negative estrogenic effects it causes on the endocrine system. That is why Regulation (EU) 2024/3190 establishes its prohibition and progressive limitation for the manufacture of FCM. In this sense, the aim of this final degree work is to study the solubility of BPA in different food simulants: n-hexane, isooctane, ethanol at 10%, 20%, 50% and 95% and acetic acid at 3%. Nephelometry was applied using the turbidimeter as an indirect solubility tool and Formazine standards were taken as a solubility threshold to classify the solutions as soluble or insoluble. The results showed that the solubility of BPA depends on both the type of simulant and the concentration of the compound, with 95% ethanol showing the highest affinity to solubilize even at concentrations of 50 mM BPA. Also, the combination of this method with visual inspection can be considered as a useful tool for the analysis of BPA.

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Published
10-11-2025
How to Cite
Soriano Meseguer, J., Bernal Conesa, V., Veiga del Baño, J. M., Oliva, J., Motas, M., & Andreo-Martínez, P. (2025). STUDY OF THE SOLUBILITY OF A-BISPHENOL IN DIFFERENT FOOD SIMULANTS. Anales De Veterinaria De Murcia, 39. https://doi.org/10.6018/analesvet.673441
Issue
Vol. 39 (2025)
Section
Trabajos Fin de Grado/Fin de Máster

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