Efecto antidiabético de Atriplex halimus en tratamiento. corto. largo plazo contra la diabetes inducida por estreptozocina

Autores/as

  • Elaid Bounouar university of Abd el hamid ibn badiss of Mostaganem
  • Fatiha MISSOUN UNIVERSITY ABD EL HAMID IBN BADISS MOSTAGANEM
  • Nesrine Ouda Amari university of Abd el hamid ibn badiss of Mostaganem
  • Fatima Zohra Belabaci university of Abd el hamid ibn badiss of Mostaganem
  • Senia Belabaci university of Abd el hamid ibn badiss of Mostaganem
  • Fatima Zohra Sekkal
  • Noureddine Djebli university of Abd el hamid ibn badiss of Mostaganem
DOI: https://doi.org/10.6018/analesbio.44.03
Palabras clave: Atriplex halimus L., Sp.Pl. 2: 1052 (1753), diabetes, fitoquímicos, estreptozotocina, glucemia.

Agencias de apoyo

  • Ministerio Argelino de Educación Superior e Investigación Científica, PRFU proyecto “D01N01UN270120190001”

Resumen

El objetivo fue evaluar la actividad antidiabética de hojas de Atriplex halimus en ratas diabéticas modelo. Para evaluar se utilizó la glicemia, pérdida de peso, volumen de consumo de agua, parámetros bioquímicos. estudio histológico. Las investigaciones fitoquímicas indican la presencia de flavonoides, taninos, saponinas, mucílagos, glucósidos. proteínas. Los resultados muestran que el tratamiento con extracto acuoso de A. halimus presenta reducción significativa de los niveles de glucosa en sangre en ratas de los grupos D100. D200, en comparación con el grupo diabético,. protege. las ratas de complicaciones diabéticas. El estudio histológico del páncreas lo confirman por la mejora en los islotes de Langerhans de rata tratada con este extracto vegetal. Atriplex halimus parece ser una planta prometedora para futuros ensayos preclínicos. clínicos en la diabetes de tipo 1.

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Biografía del autor/a

Elaid Bounouar , university of Abd el hamid ibn badiss of Mostaganem

Laboratory  of Pharmacognosy and Api-Phytotherapy, University of Mostaganem (UMAB), Mostaganem 27000, Algeria. 

Nesrine Ouda Amari, university of Abd el hamid ibn badiss of Mostaganem

Laboratory  of Pharmacognosy and Api-Phytotherapy, University of Mostaganem (UMAB), Mostaganem 27000, Algeria.

Fatima Zohra Sekkal

Laboratory of biodiversity and conservation of water and soil ,University of Mostaganem (UMAB), Mostaganem 27000, Algeria

Noureddine Djebli , university of Abd el hamid ibn badiss of Mostaganem

Laboratory  of Pharmacognosy and Api-Phytotherapy, University of Mostaganem (UMAB), Mostaganem 27000, Algeria

Citas

American Diabetes Association. 2020. Older Adults: Standards of Medical Care in Diabetes – 2020. Diabetes Care 43(S1): S152-S162. https://doi.org/10. 2337/dc20-S012.

Allaoui M, Cheriti A, Chebouat E, Dadamoussa B & Gherraf N. 2016. Comparative study of the antioxidant activity and phenols and flavonoids contents of the ethyl acetate extracts from two Saharan chenopodacea: Haloxylon scoparium and Traganum nudatum. Algerian Journal of Arid and Environment 6(1): 71-79.

Alwashli A, Al-sobarry M, Alnamer R, Cherrah Y & Alaoui K. 2012. Analgesic and anti-inflammatory activities of Boswellia elongata balf methanolic extracts, as endemic plants in Yemen, Journal of Biologically Active Products from Nature 2(2): 90–98. https://doi.org/10.1080/22311866.2012.10719 114

Atmani D, Chaher N, Berboucha M, Ayouni K, LounisH, Boudaoud H, . . . Atmani D. 2009. Antioxidant capacity and phenol content of selected Algerian medicinal plants. Food Chemistry 112(2): 303-9. https://doi. org/10.1016/j.foodchem.2008.05.077

Ayoola GA, Coker HA, Adesegun SA, Adepoju-Bello AA, Obaweya KE & Atangbayila TO. 2008. Phytochemical screening and antioxidant activities of some selected medicinal plants used for malaria therapy in Southwestern Nigeria. Tropical Journal of Pharmalogical Research. 7(3): 1019-1024 .

Bancroft JD & Gamble M. 2008. Theory and practice of histological techniques. London: Churchill Livingstone.

Benhammou N, Bekkara F & Tatjana P. 2009. Antioxidant activity of methanolic extracts and some bioactive compounds of Atriplex halimus. Comptes Rendus Chimie 12(12): 1259-1266. https://doi.org/10. 1016/j.crci.2009.02.004.

Chikhi I, Allali H, Dib MEA, Medjdoub H & Tabti B. 2014. Antidiabetic activity of aqueous leaf extract of Atriplex halimus L. (Chenopodiaceae) in streptozotocin-induced diabetic rats. Asian Pacific Journal of Tropical Disease 4(3):181-4. https://doi.org/10.1016/S2222-1808(14) 60501-6

Clauser M, Dall'Acqua S & Loi MC. 2013. Phytochemical investigation on Atriplex halimus from Sardinia. Natural Product Research 27(20): 1940-1944. https://doi.org/10.1080/14786419.2013.793684

Devika M,Joshi H & Nalini MS. 2016. Phytochemicals, antioxidative and in vivo hepatoprotective potentials of Litsea floribunda (BL.) Gamble (Lauraceae) - An endemic tree species of the Southern Western Ghats, India. Jordan Journal of Biological Sciences 9(3): 163. 171.

Dhifi W, Jelali N, Chaabani E, Beji M, Fatnassi S & Omri S. 2013. Chemical composition of Lentisk (Pistacia lentiscus L.) seed oil. African Journal of Agricultural Research 8(16): 1395-1400. https://doi.org/10.5897/AJAR11.1837.

Emam SS. 2010. Bioactive constituents of Atriplex halimus plant. Journal of Natural Products 4: 25-41.

Evans WC & Evans D. 2009. Trease and Evans' Pharmacognosy. Elsevier

Gattouche S, Zenkhri L, Lakhdar BM & Tabchouche A. 2020. Phytochemical Screening, Anti-Bacterial and Anti-oxidant Activities of some Aerial parts extracts in Atriplex halimus L., from Ouargla (Algeria) .Asian Journal of Research in Chemistry 13(5): 365-372. https://doi.org/10.5958/0974-4150.2020.00069.3.

Goyal M & Kaur R. 2019. Interactive effect of nitrogen nutrition, nitrate reduction and seasonal variation on oxalate synthesis in leaves of Napier-bajra hybrid (Pennisetum purpureum x P. glaucum). Crop and Pasture Science 70(8): 669-675. https://doi.org/10. 1071/CP18282.

Hamza N, Berke B, Umar A, Cheze C, Gin H & Moore N. 2019. A review of Algerian medicinal plants used in the treatment of diabetes. Journal of Ethnopharmacolgy 238: 111841. https://doi.org/10.1016/j.jep. 2019.111841.

Harborne JB. 1998. Textbook of phytochemical methods. A guide to modern techniques of plant analysis. New York: Chapman and Hall Int.

Kumari S, Wanjari M, Kumar P & Palani S. 2012. Antidiabetic activity of Pandanus fascicularis Lamk aerial roots in alloxan-induced hyperglycemic rats. International Journal of Nutrition, Pharmacology, Neurological Diseases 2(2): 105-110. https://doi.org/10.4103/ 2231-0738.95943

Lowry OH, Rosebrough NJ, Farr AL & Randall RJ. 1951. Protein Measurement with the Folin phenol reagent. Journal of Biological Chemistry 193: 265-275. https://doi.org/10.1016/S0021-9258(19)52451-6

Marella S. 2018. Antidiabetic plant proteins/peptides as complementary and alternative medicine - analytical perspectives. Reviews in Analytical Chemistry 37(4): [20] https://doi.org/10.1515/revac-2017-0025

McGill MR. 2016 .The past and present of serum aminotransferases and the future of liver injury biomarkers. EXCLI journal 15: 817-828. https://doi.org/10.17179/excli2016-800

Metawea RR & Shaheen KA. 2021. Study of the potential impact of Atriplex halimus L. (Chenopodiaceae) on experimental animals infected with hypergly­cemia. Journal of Home Economics 2021, 31(2): 1-13. https://dx.doi.org/10.21608/mkas.2021.197513

Missoun F, Bouabdelli F, Baghdad A, Amari O & Djebli N. 2018. Antidiabetic bioactive compounds from plants. Medical Technologies Journal 2(2): 199-214. https://doi.org/10.26415/2572-004X-vol2iss2p199-214.

Mostafavinia A, Amini A, Ghorishi SK, Pouriran R & Bayat M. 2016. The effects of dosage and the routes of administrations of streptozotocin and alloxan on induction rate of type1 diabetes mellitus and morta­lity rate in rats. Laboratory Animal Research 32(3): 160-165. https://doi.org/10.5625/lar.2016.32.3.160.

OECD/OCDE. 2002. Test No. 423: Acute Oral toxicity - Acute Toxic Class Method. OECD Guidelines for the Testing of Chemicals. Paris: OECD Publishing. https://doi.org/10.1787/9789264071001-en.

Ould Kaddour AS, Bouzouina M & Lotmani B. 2019. Phenolics contents and in-vitro evaluation of the antioxidant effects of the aerial parts of three Algerian Atriplex halimus. Ecotypes. Plant Archives 19(1): 1583-1592.

Ounaissia K, Bennadja S, Aliane L & Djahoudi A. 2020. Phytochemical screening and anti-bacterial activity of methanolic extracts of the aerial parts of Atriplex halimus from Biskra (Algeria). International Journal of Agricultural and Natural Sciences 13(1): 26-33.

Slama K, Boumendjel M, Taibi F, Boumendjel A & Messarah M. 2020. Atriplex halimus aqueous extract abrogates carbon tetrachloride-induced hepatotoxicity by modulating biochemical and histological changes in rats. Archives of Physiology and Biochemistry 126(1): 49-60. https://doi.org/10.1080/13813455. 2018.1489852

Sofowara A. 1993. Medicinal plants and traditional medicine in Africa. Ibadan, Nigeria: Spectrum Books Ld.

Suba V, Murugesan T, Bhaskara Rao R, Ghosh L, Pal M, . . . Saha BP. 2004. Antidiabetic potential of Barleria lupulina extract in rats. Fitoterapia. 75(1):1-4. https://doi.org/10.1016/s0367-326x(03)00163-1

Wolf PL, Williams D, Tsudaka T & Acosta L. 1972. Me­thods and techniques in clinical chemistry. New York: John Wiley. Sons.

World Bank. 2020. World Development Indicators. Algeria-Diabetes Prevalence (% of population ages 20 to 79). Available in https://tradingeconomics.com/alge ria/diabetes-prevalence-percent-of-population-ages-20-to-79-wb-data.html (Accessed on 1-II-2021).

World Health Organization. 2020. Diabetes. Available in https://www.who.int/health-topics/diabetes (Acces­sed on 1-II-2021).

Publicado
10-05-2022
Cómo citar
Bounouar , E. ., MISSOUN, F., Amari, . N. O. ., Belabaci, F. Z., Belabaci , S. ., Sekkal , F. Z. ., & Djebli , N. . (2022). Efecto antidiabético de Atriplex halimus en tratamiento. corto. largo plazo contra la diabetes inducida por estreptozocina. Anales de Biología, (44), 21–30. https://doi.org/10.6018/analesbio.44.03
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