Evaluation of the antibacterial and modulatory activities of ethanolic excract of Calotropis procera (Aiton) W.T. Aiton against multiresistant bacterial strains

Antibacterial effect of C. Procera

Authors

  • Yuri Geraldo
  • Livia Leandro
  • Ana Raquel Silva
  • Fábia Campina
  • Ana Carolina Araújo
  • Priscilla Freitas
  • Antonia Santos
  • Janaina Rocha
  • Irwin Menezes
  • Henrique Douglas Melo Coutinho Department of Biological Chemistry, Regional University of Cariri, Crato 63105-000, Brazil
DOI: https://doi.org/10.6018/analesbio.43.19
Keywords: Modulation, Calotropis procera, Resistance

Abstract

The objective of this study was to evaluate the antibacterial and modulatory activities of ethanolic extract of Calotropis procera (Aiton) W.T. Aiton against resistant species. By microdilution method, the minimum inhibitory concentration (MIC) of the extract and modulation of the subinhibitory concentration MIC/8 to norfloxacine, gentamicin and imipenem against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. There was obtained 512 μg/mL to Pseudomonas aeruginosa. To Staphylo­coccus aureus, modulation showed synergism to norfloxacin and gentamicin, with imipenem against Pseudomonas aeruginosa and gentamicin against Escherichia coli. Based on these results, more studies are needed to test the antibacterial activity of the extract.

Downloads

Download data is not yet available.

References

Aguiar JJ, Sousa CP, Araruna MK, Silva MKN, Portelo AC, Lopes JC, . . . Matias EFF. 2015. Antibacterial and modifying-antibiotic activities of the essential oils of Ocimum gratissimum L. and Plectranthus amboinicus L. European Journal of Integrative Medicine 7:151-156. https://doi.org/10.1016/j.eujim.2014.10. 005

Brito SA, Coutinho HDM, Barros ARC, Rodrigues, FFG & Costa JGM. 2010. Prospecção fitoquímica e avaliação da atividade antibacteriana e toxicidade do látex de Calotropis procera (Asclepidaceae). Cadernos de Cultura e Ciências URCA 2: 31-39.

CLSI - Clinical and Laboratory Standards Institute. 2012. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; Approved standard – Ninth edition. Wayne, PA: NIH.

Costa NDJ, Oliveira SFC, Silva JN, Pacheco ACL, Abreu MC, Cavalcante AAC, . . . Ferreira PMP. 2015. Potencial terapêutico e tecnológico da planta Calotropis procera. Revista Geintec, gestão, inovação e tecnologias 5:2222-2236. https://doi.org/10.7198/geintec.v5i3.434

Coutinho HDM, Costa JGM, Lima EO, Falcão-Silva VS & Siqueira-Júnior JP. 2008a. Enhancement of the antibiotic activity against a multiresistant Escherichia coli by Mentha arvensis L. and chlorpromazine. Chemotherapy 54: 328-330. https://doi.org/10.1159/ 000151267

Coutinho HDM, Costa JGM, Siqueira-Júnior JP & Lima EO. 2008b. In vitro anti-staphylococcal activity of Hyptis martiusii Benth against methicillin-resistant Staphylococcus aureus: MRSA strains. Revista Brasileira de Farmacognosia 18: 670-675. https://doi.org/10.1590/S0102-695X2008000500005

Fabricante JR, Oliveira MNA & Siqueira-Filho JÁ. 2013. Aspectos da ecologia de Calotropis procera (Apocynaceae) em uma área de Caatinga alterada pelas obras do Projeto de Integração do Rio São Francisco em Mauriti, CE. Rodriguésia 64: 647-654. https://doi.org/10.1590/S2175-78602013000300015

Franco AL. 2007. Avaliação da composição química e atividade antibacteriana dos óleos essenciais de Aloysia gratissima (Gillies&Hook) Tronc. (alfazema), Ocimum gratissimum L.(alfavaca-cravo) e Curcuma longa L.(açafrão). Revista Eletrônica de Farmácia 4: 208-220. https://doi.org/10.5216/ref.v4i2.3063

Javadpour MM, Juban MM, Lo WCJ, Bishop SM, Alberty JB, Cowell SM, . . . McLaughlin ML. 1996. De novo antimicrobial peptides with low mammalian cell toxicity. Journal of Medicinal Chemistry 39: 3107-3113. https://doi.org/10.1021/jm9509410

Matias EFF, Alves EF, Santos BS, Sobral-Souza, CE, Alencar-Ferreira JV, Lavor AKLS, . . . Costa JGM. 2013. Biological activities and chemical characterization of Cordia verbenacea DC. As tool to validate the ethnobiological usage. Evidence-Based Complementary and Alternative Medicine 1-7. https://doi. org/10.1155/2013/164215

Morais-Braga MFB, Souza TM, Santos KKA, Guedes GMM, Andrade JC, Tintino SR, . . . Coutinho HDM. 2013. Atividade antibacteriana, antifúngica e moduladora da atividade antimicrobiana de frações obtidas de Lygodium venustum SW. Boletin Latinoamericano y del Caribe sobre Plantas Medicinales y Aromaticas 12: 38-43.

Oliveira AC & Silva RS. 2009. Desafios do cuidar em saúde frente à resistência bacteriana: uma revisão. Revista Eletronica de Enfermagem, 10:189-197. https://doi.org/10.5216/ree.v10i1.8011

Quazi S, Mathur K & Arora S. 2013. Calotropis procera: An overview of its phytochemistry and pharma­cology. Indian Journal of Drugs, 1: 63-9.

Santos NQ. 2004. A resistência bacteriana no contexto da infecção hospitalar. Texto e contexto enfermagem 13: 64-70. https://doi.org/10.1590/S01 04-07072004000500007

Tintino SR, Cunha FAB, Santos KKA, Guedes GMM, Souza CES, Matias EFF . . . Coutinho HDM. 2013. Atividade moduladora de extratos etanólico e hexânico de raiz de Costus cf. arabicus sobre drogas antimicrobianas. Revista Brasileira de Biociências 11: 157-162.

Tomazzoni MI, Negrelle RRB & Centa MDL. 2006. Fitoterapia popular: A busca instrumental enquanto prática terapêuta. Texto e Contexto Enfermagem 15: 115-121. https://doi.org/10.1590/S0104-070720060 00100014

Published
21-12-2021
How to Cite
Geraldo, Y., Leandro, L., Silva, A. R., Campina, F., Araújo, A. C., Freitas, P., … Coutinho, H. D. M. (2021). Evaluation of the antibacterial and modulatory activities of ethanolic excract of Calotropis procera (Aiton) W.T. Aiton against multiresistant bacterial strains: Antibacterial effect of C. Procera. Anales de Biología, (43), 205–209. https://doi.org/10.6018/analesbio.43.19
Issue
No. 43 (2021)
Section
Articles

Copyright (c) 2021 Anales de Biología

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Las obras que se publican en esta revista están sujetas a los siguientes términos:

1. El Servicio de Publicaciones de la Universidad de Murcia (la editorial) conserva los derechos patrimoniales (copyright) de las obras publicadas, y favorece y permite la reutilización de las mismas bajo la licencia de uso indicada en el punto 2.

2. Las obras se publican en la edición electrónica de la revista bajo una licencia Creative Commons Reconocimiento-NoComercial-SinObraDerivada 3.0 España (texto legal). Se pueden copiar, usar, difundir, transmitir y exponer públicamente, siempre que: i) se cite la autoría y la fuente original de su publicación (revista, editorial y URL de la obra); ii) no se usen para fines comerciales; iii) se mencione la existencia y especificaciones de esta licencia de uso.

Licencia Creative Commons

3. Condiciones de auto-archivo. Se permite y se anima a los autores a difundir electrónicamente las versiones pre-print (versión antes de ser evaluada) y/o post-print (versión evaluada y aceptada para su publicación) de sus obras antes de su publicación, ya que favorece su circulación y difusión más temprana y con ello un posible aumento en su citación y alcance entre la comunidad académica. Color RoMEO: verde.

Most read articles by the same author(s)