Condiciones post COVID-19: un análisis de la fatiga y factores asociados
Resumen
Objetivo: Estimar a prevalência de fadiga pós-COVID-19 autorreferida e analisar fatores associados entre residentes do estado da Paraíba, Brasil.
Método: Trata-se de um estudo transversal, do tipo survey online. A coleta de dados ocorreu entre março de 2023 e março de 2024. Foram realizadas estatísticas descritivas e inferenciais. Os preceitos éticos foram respeitados.
Resultados: Foram incluídos 263 participantes, predominantemente do sexo feminino, na faixa etária de 21 a 40 anos, que receberam diagnóstico de Covid-19 apenas uma vez, classificaram sua infecção aguda como leve, estavam vacinados contra Covid-19, não fumavam e consumiam bebidas alcoólicas. A prevalência de fadiga pós-COVID-19 autorrelatada foi de 90,5%. Indivíduos que relataram sintomas persistentes por mais de quatro semanas após a infecção (OR: 5,55; p=0,000) e aqueles que consumiram bebidas alcoólicas (OR: 2,88, p=0,010) foram considerados mais propensos a apresentar fadiga.
Conclusões: A fadiga é o sintoma mais prevalente das condições pós-COVID-19 e foi associada à persistência dos sintomas e ao consumo de álcool.
Palavras-chave: Síndrome Pós-COVID-19 Aguda; Fadiga; COVID 19; Consumo de bebidas alcoólicas.
Descargas
Citas
National Academies of Sciences, Engineering, and Medicine. A Long COVID definition: A chronic, systemic disease state with profound consequences. Washington, DC: The National Academies Press. 2024. Doi: https://doi.org/10.17226/27768
Hartung TJ, Bahmer T, Chaplinskaya-Sobol I, Deckert J, Endres M, Franzpotter K, et al. Predictors of non-recovery from fatigue and cognitive deficits after COVID-19: a prospective, longitudinal, population-based study. EClinicalMedicine. 2024; 69:102456. Doi: https://doi.org/10.1016/j.eclinm.2024.102456
Luo D, Mei B, Wang Piao, Li X, Chen X, Wei G, et al. Prevalence and risk factors for persistent symptoms after COVID-19: a systematic review and meta-analysis. Clin Microbiol Infect. 2024; 30(3):328-35. Doi: https://doi.org/10.1016/j.cmi.2023.10.016
Malik P, Patel K, Pinto C, Jaiswal R, Tirupathi R, Pillai S, et al. Post-acute COVID-19 syndrome (PCS) and health-related quality of life (HRQoL)-A systematic review and meta-analysis. J Med Virol. 2022; 94(1):253-62. Doi: https://doi.org/10.1002/jmv.27309
Ceban F, Ling S, Lui LMW, Lee Y, Gill H, Teopiz KM, et al. Fatigue and cognitive impairment in Post-COVID-19 Syndrome: A systematic review and meta-analysis. Brain Behav Immun. 2022; 101:93-135. doi: https://doi.org/10.1016/j.bbi.2021.12.020
Premraj L, Kannapadi NV, Briggs J, Seal SM, Battaglini D, Fanning J, et al. Mid and long-term neurological and neuropsychiatric manifestations of post-COVID-19 syndrome: A meta-analysis. J Neurol Sci. 2022; 434:120162. Doi: https://doi.org/10.1016/j.jns.2022.120162
Campos MC, Nery T, Starke AC, de Bem Alves AC, Speck AE, S Aguiar A. Post-viral fatigue in COVID-19: A review of symptom assessment methods, mental, cognitive, and physical impairment. Neurosci Biobehav Rev. 2022; 142:104902. Doi: https://doi.org/10.1016/j.neubiorev.2022.104902
Aiyegbusi OL, Hughes SE, Turner G, Rivera SC, McMullan C, Chandan JS, et al. Symptoms, complications and management of long COVID: a review. J R Soc Med. 2021; 114(9):428-42. Doi: https://doi.org/10.1177/01410768211032850
Valliant R, Dever J, Kreuter F. Practical Tools for Designing and Weighting Survey Samples. Statistics for Social and Behavioral Sciences. 2013; 51:203-255. Disponível em: https://link.springer.com/chapter/10.1007/978-1-4614-6449-5_9
Miranda DAP, Gomes SVC, Filgueiras PS, Corsini CA, Almeida NBF, Silva RA, et al. Long COVID-19 syndrome: a 14-months longitudinal study during the two first epidemic peaks in Southeast Brazil. Transactions of The Royal Society of Tropical Medicine and Hygiene. 2022; 116(11). Doi: https://doi.org/10.1093/trstmh/trac030
Cochran WG. Sampling Techniques. 3. ed. John Wiley & Sons: New York; 1977.
Nehme M, Braillard O, Chappuis F, Courvoisier DS, Guessous I. Persistent fatigue and cognitive impairment following COVID-19: a population-based cohort study. Lancet Regional Health Europe. 2022;12:100284. Doi: https://doi.org/10.1016/j.lanepe.2021.100284
Sudre CH, Murray B, Varsavsky T, Graham MS, Penfold RS, Bowyer RC, et al. Attributes and predictors of long COVID. Nat Med. 2021;27(4):626-31. Doi: https://doi.org/10.1038/s41591-021-01292-y
Nehme M, Chappuis F, Kaiser L, Assal F, Guessous I. The Prevalence, Severity, and Impact of Post-COVID Persistent Fatigue, Post-Exertional Malaise, and Chronic Fatigue Syndrome. J Gen Intern Med. 2023;38:835-9. Doi: https://doi.org/10.1007/s11606-022-07882-x
Townsend L, Dyer AH, Jones K, Dunne J, Mooney A, Gaffney F, et al. Persistent fatigue following SARS-CoV-2 infection is common and independent of severity of initial infection. PLoS One. 2020;15(11):e0240784. Doi: https://doi.org/10.1371/journal.pone.0240784
Carfi A, Bernabei R, Landi F. Persistent symptoms in patients after acute COVID-19. JAMA. 2020; 324(6):603-5. Doi: https://doi.org/10.1001/jama.2020.12603
Huang C, Huang L, Wang Y, Li X, Ren L, Gu X, et al. 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. Lancet. 2021; 397(10270):220-32. Doi: https://doi.org/10.1016/S0140-6736(20)32656-8
Goërtz YM, Herck MV, Delbressine JM, Vaes AW, Meys R, Machado FV, et al. Persistent symptoms 3 months after a SARS-CoV-2 infection: the post-COVID-19 syndrome?. ERJ Open Res. 2020;6(4):00542-2020. Doi: https://doi.org/10.1183/23120541.00542-2020
Guarnieri JW, Dybas JM, Fazelinia H, Kim MS, Frere J, Zhang Y, et al. Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts. Sci Transl Med. 2023;15(708):eabq1533. Doi: https://doi.org/10.1126/scitranslmed.abq1533
Gain C, Song S, Angtuaco T, Satta S and Kelesidis T. The role of oxidative stress in the pathogenesis of infections with coronaviruses. Front Microbiol. 2023; 13(1111930). Doi: https://doi.org/10.3389/fmicb.2022.1111930
Mohandas S, Jagannathan P, Henrich TJ, Xerife ZA, Bime C, Quilan E, et al. Immune mechanisms underlying COVID-19 pathology and post-acute sequelae of SARS-CoV-2 infection (PASC). eLife. 2023; 12. Doi: https://doi.org/10.7554/eLife.86014
Walker S, Goodfellow H, Pookarnjanamorakot P, Murray E, Bindman J, Blandford A, et al. Impact of fatigue as the primary determinant of functional limitations among patients with post-COVID-19 syndrome: a cross-sectional observational study. BMJ Open. 2023;13. Doi: https://doi.org/10.1136/bmjopen-2022-069217
Carvalho-Schneider C, Laurent E, Lemaignen A, Beaufils E, Boubao-Tournois C, Laribi D, et al. Follow-up of adults with non-critical COVID-19 two months after symptom onset. Clin Microbiol Infect. 2021; 27(2):258-63. Doi: https://doi.org/10.1016/j.cmi.2020.09.052
Azzam A, Khaled H, Refaey N, Mohsen S, El-Eman AO, Dawood N, et al. The burden of persistent symptoms after COVID-19 (long COVID): a meta-analysis of controlled studies in children and adults. Virol J. 2024; 21:16. Doi: https://doi.org/10.1186/s12985-024-02284-3
Byambasuren O, Stehlik P, Clark J, Alcorn K, Glasziou P. Effect of covid-19 vaccination on long covid: systematic review. BMJ Medicine. 2023; 2:e000385. Doi: https://doi.org/10.1136/bmjmed-2022-000385
Reardon S. Long COVID risk falls only slightly after vaccination, huge study shows. Nature. 2022. Doi: https://doi.org/10.1038/d41586-022-01453-0
Ledford H. Do vaccines protect against long COVID? What the data say. Nature. 2021; 599(7886):546-8. Doi: https://doi.org/10.1038/d41586-021-03495-2
Malik M, Yagan L, Zakaria D. New onset of acute and chronic hepatic diseases post-COVID-19 infection: a systematic review. Biomedicines. 2024; 12(9):2065. Doi: https://doi.org/10.3390/biomedicines12092065
Logue JK, Franko NM, McCulloch DJ, Mcdonald D, Magedson A, Lobo CR, et al. Sequelae in adults at 6 months after COVID-19 infection. JAMA Netw Open. 2021; 4(2). Doi: https://doi.org/10.1001/jamanetworkopen.2021.0830
-
Resumen58
-
ESP_PDF19
-
ENG_PDF (English)14
Derechos de autor 2025 Enfermería Global
Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-SinDerivadas 4.0.
Las obras que se publican en esta revista están sujetas a los siguientes términos:
1. El Servicio de Publicaciones de la Universidad de Murcia (la editorial) conserva los derechos patrimoniales (copyright) de las obras publicadas, y favorece y permite la reutilización de las mismas bajo la licencia de uso indicada en el punto 2.
© Servicio de Publicaciones, Universidad de Murcia, 2018
2. Las obras se publican en la edición electrónica de la revista bajo una licencia Creative Commons Reconocimiento-NoComercial-SinObraDerivada 4.0 España (texto legal). Se pueden copiar, usar, difundir, transmitir y exponer públicamente, siempre que: i) se cite la autoría y la fuente original de su publicación (revista, editorial y URL de la obra); ii) no se usen para fines comerciales; iii) se mencione la existencia y especificaciones de esta licencia de uso.
3. Condiciones de auto-archivo. Se permite y se anima a los autores a difundir electrónicamente las versiones pre-print (versión antes de ser evaluada y enviada a la revista) y/o post-print (versión evaluada y aceptada para su publicación) de sus obras antes de su publicación, ya que favorece su circulación y difusión más temprana y con ello un posible aumento en su citación y alcance entre la comunidad académica. Color RoMEO: verde.
