SILYMARIN AND (+)-CYANIDANOL-3 PHARMACOKINETICS IN CHICKEN
Abstract
Silymarin and (+)-cyanidanol-3 are two natural compounds with markedly antihepatotoxic activity. Each compound was administered separalely by intravenous injection at dose levels of 40.2 and 50 mg/kg of body weight respeclively. The data were adequalely explained by the two-compartment open model and therefore, a two exponential quations was established for each compound: C = 157,18 · e-0.1472-t + 177,12 · e-0.0141-t mg/L y C = 54,08 · e-0.1784-t + 13,57 · e-0.0234-t mg/L The main kinelic paramelers of each compound were deduced fram these equations. It can be concluded that it is the rapid elimination of bolh these drugs that reduces the possibility of their therapeutics use.Downloads
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