INTRAVENOUS PHARMACOKINETICS OF OXYTETRACYCLINE-CALCIUM ASSOCIATION IN HEN

Authors

  • M. E. Guimerá
  • I. Rosado
  • C. M. Cárceles
  • C. J. Ponferrada
  • J. M. Serrano
Keywords: farmacocinética, oxitetraciclina, calcio, gallinas

Abstract

Oxytetracycline can form quelates with calcium and other metals, resulting in possible pharmacokinetic modifications.The purpose of this study was to establish the pharmacokinetics of the OTC-HCI/CaCI2 association after intravenous administration to hens. The antibiotic solution composed of OTC-HCI (0.02 M) and CaCI2 (0.01 M), was repared immediately before the administration and injected at dose of 1 mL/Kg b.w. (10 mgkg b.w.). Blood samples were drawn at different times. The quantification of OTC in plasma was carried out by HPLC methods. Plasma concentration data was fitted to different compartment models, and finally, a three-compartment open model was chosen as the most accurate. As for the weighting of data, the best fitting were obtained without a different weight coefficient (l/Cp0) in six animals and with a weight coefficient inverse to the plasma concentration (l/Cp1) in four animals. Pharmacokinetic parameters were determine corresponding to one central compartment with elimination and distribution to two peripheral compartments without transfer of dmg between them.

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Author Biographies

M. E. Guimerá

Departamento de Farinacología y Toxicología Facultad de Veterinaria Universidad de Córdoba Becaria de F.P.I. del M.E.C.

I. Rosado

Departamento de Farinacología y Toxicología Facultad de Veterinaria Universidad de Córdoba

C. M. Cárceles

Departamento de Ciencia, Socio-sanitarias Facultad de Veterinaria Universidad de Murcia

C. J. Ponferrada

Departamento de Farinacología y Toxicología Facultad de Veterinaria Universidad de Córdoba

J. M. Serrano

Departamento de Farinacología y Toxicología Facultad de Veterinaria Universidad de Córdoba Director del trabajo de beca de F.P.I.
How to Cite
Guimerá, M. E., Rosado, I., Cárceles, C. M., Ponferrada, C. J., & Serrano, J. M. (1992). INTRAVENOUS PHARMACOKINETICS OF OXYTETRACYCLINE-CALCIUM ASSOCIATION IN HEN. Anales de Veterinaria de Murcia, 8, 55–62. Retrieved from https://revistas.um.es/analesvet/article/view/19101
Issue
Vol. 8 (1992)
Section
Trabajos Fin de Grado/Fin de Máster

 

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