PHARMACOKINETICS OF OXYTETRACYCLINE IN SHEEP AND GOATS
Abstract
The pharmacokinetic behavior of a conventional formulation of oxytetracycline was studied after intravenous administration to five sheep arid ten goats to determine if there are species differences in disposition. The antibiotic is distributed according to an open two-compartment model in both species. The plasma drug concentration vs time following intravenous administration of 10 mg/kg were best described by the biexponential equations C = 16'389 e-1,603t + 5'853 e-0,109t for goats, and C = 18'658 e-1'713t + 6'158 e-0,116t for sheep. The half-lives for goats and sheep were 6 h 28 min and 6 h 9 min respectively and were not significantly different. The total body clearances for sheep and goats were 0.154 and 0.156 L/kg/h respectively. There were significant dilferences between the apparent volumes of the peripheral compartment (Vp).Downloads
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