CONCENTRACIONES SÉRICAS DE HORMONA DE CRECIMIENTO EN PERRAS CON TUMORES MAMARIOS  ESPONTÁNEOS ANTES Y DESPUÉS DE LA MASTECTOMÍA

Y. Corrada; R. G. Goya; C. Cobello

GROWTH HORMONE SERUM CONCENTRATIONS IN BITCHES WITH SPONTANEOUS MAMMARY TUMORS BEFORE AND AFTER MASTECTOMY

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Authors

Y. Corrada
R. G. Goya
C. Cobello

Keywords: growth hormone, mammary tumor, mastectomy, bitch

Abstract

An autonomous non-pituitary production of growth hormone GH in the mammary gland has been reported in dogs. To assess the impact of mastectomy of tumoral glands on GH serum concentrations in clinical cases of spontaneous mammary tumors in eighteen intact bitches mastectomy of all tumoral glands was carried out. Three healthy bitches were maintained under the anaesthesic protocols for a similar period to the surgical procedure. Blood samples for GH determination were taken by peripheral venipuncture before (day –1), 2 and 11 hours and 7 and 14 days after mastectomy or anaesthesia. Tissue samples of the tumoral mammary glands of Group 1 were histologicaly examined. Serum GH was measured by a homologous liquid phase radioimmunoassay. Histology findings were tubular (n=2) and papillary carcinoma (n=4), tubular adenocarcinoma (n=8), carcinosarcoma (n=3) and complex carcinoma (n=1). Mean +-SEM serum GH concentrations (ng/ml) of the treated group before and after surgery were 17.3+-2.8; 8.5+-1.5; 6.3+-1.1 and 6.1+-1.5 for –1 day, 2 hours, 7 and 14 days, respectively. The same values for the sham group were 4.2+-1.0; 5.5+-1.3 and 5.2 +-1.5 for –1 day, 2 and 11 hours after anesthesia. After surgery, serum GH showed a decrease (mean +-SEM) of –22.6 % +-4.9 at 2 hours, -31.8 % +-5.1 on day 7, and -29.7% +-9 on day 15 while it increased to 31.1 % +-08 and 26.3 % +-9 at 2 hours and 11 hours, respectively after anesthesia in the sham group. It is concluded that in bitches ectopic GH is produced also by spontaneous malignant mammary gland tumors.

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Author Biographies

Y. Corrada

Imaging Diagnose Service Faculty of Veterinary Sciences National University of La Plata Argentina

R. G. Goya

INIBIOLP-Histology B Faculty of Medicine National University of La Plata Argentina

C. Cobello

Imaging Diagnose Service Faculty of Veterinary Sciences National University of La Plata Argentina

How to Cite

Corrada, Y., Goya, R. G., & Cobello, C. (2003). GROWTH HORMONE SERUM CONCENTRATIONS IN BITCHES WITH SPONTANEOUS MAMMARY TUMORS BEFORE AND AFTER MASTECTOMY. Anales de Veterinaria de Murcia, 19, 37–42. Retrieved from https://revistas.um.es/analesvet/article/view/17141

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Issue

Vol. 19 (2003)

Section

Trabajos Fin de Grado/Fin de Máster

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