RETROSPECTIVE STUDY OF CHRONIC COPPER POISONING IN SHEEP
Abstract
A retrospective survey was conducted on 112 cases of chronic copper poisoning in sheep diagnosed at the Iowa State University Veterinary Diagnostic Laboratory over a six year period. Animals that died with signs and lesions of a hemolytic crisis had mean (+-SD) liver and kidney copper concentrations of 268.5+-100.4 ppm and 49.9+-36.2 ppm (wet weight), respectively. Kidney values were increased from normal values more consistently than liver values in animals that died with signs of a hemolytic crisis; thus, kidney is considered the tissue of choice when measurement of only one organ is requested. Analysis of 35 feed samples revealed ratios of copper:molybdenum greater than 10:1. This report also addresses recent findings on the pathogenesis and kinetics of chronic copper poisoning and the different treatment protocols recommended.Downloads
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