USE OF AVIAN MODELS FOR HUMAN ATHEROSCLEROSIS RESEARCH
Abstract
Avian models were some of the first animal models of atherosclerosis to be studied. This work presents the four species used for the vast majority of these studies (chicken, pigeon, Japanese quail and turkey). It summarizes the advantages and disadvantages of their use and analyses their contribution to the comprehension of atherosclerosis. These animal models have provided unique insights into specific aspects of atherosclerosis, including the role of genetic factors, viruses, estrogens and hypertension in susceptibility to atherosclerosis, and have been used extensively to study cellular and molecular mechanisms in the pathogenesis of atherosclerosis.Downloads
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