An immunohistochemical study of cyclooxygenase-2 expression in canine multicentric lymphoma

Authors

  • L. C. S. Rodrigues
  • B. Cogliati
  • J. L. Guerra
  • M. L. Z. Dagli
  • Sílvia Sílvia Regina Ricci Lucas
DOI: https://doi.org/10.6018/j/160131
Keywords: cancer, dogs, immunohistochemistry, COX-2, lymphoma

Abstract

Cyclooxygenase-2 (COX-2) expression has been associated with development and progression in spontaneous human and dogs tumors. Studies demonstrated that non-steroidal anti-inflammatory drugs, which inhibit COX enzyme, may be used in the treatment of some tumors. Lymphoma is a systemic disease and the most common hematological malignancy in dogs. There are few studies about COX-2 expression in human and canine lymphoma. In this study, immunohistochemical evaluation for COX-2 expression was performed in 12 dogs with multicentric lymphoma. The diagnosis was confirmed by histopathological examination. Six samples of normal lymph nodes were either used in the study. No COX-2 immunoreactivity was detected in all samples from canine lymphoma and normal lymph nodes, as well previous studies in canine lymphoma.

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How to Cite
Rodrigues, L. C. S., Cogliati, B., Guerra, J. L., Dagli, M. L. Z., & Lucas, S. S. R. R. (2011). An immunohistochemical study of cyclooxygenase-2 expression in canine multicentric lymphoma. Anales de Veterinaria de Murcia, 27, 43–49. https://doi.org/10.6018/j/160131
Issue
Vol. 27 (2011)
Section
Trabajos Fin de Grado/Fin de Máster

 

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