Assessment of aglepristone in dogs with mammary tumors stage V

Authors

  • Guillermo Hermo Universidad Nacional de Quilmes
  • Mirian Villanueva Servicio de Radiología
  • Pablo Segura Servicio de Radiología
  • Daniel Alonso Universidad Nacional de Quilmes
  • Cristina Gobello Universidad Nacional de La Plata
Keywords: metastasis, neoplasm, mammary gland, aglepristone, treatment

Abstract

Pulmonary metastasis of breast tumours is usually the cause of death in pets suffering a mammary gland neoplasm. This marks the importance of fi nding new treatments, focusing on the modulation of molecular targets, with a predominant in the stabilization or regression of metastasis disease. In this study included 20 dogs with mammary tumours in V clinical stage. The dogs were randomly placed in one of the following treatments. Aglespristone (Alizine ®, Virbac, France) (Agle, n = 10) or placebo (PLCB n = 10). Survival analysis by Kaplan-Meier method indicated that aglepristone not extended the median time of general survival (Agle. 13 days vs PLCB 14.5 days (P = 0.8). This application pattern in the aglepristone treatment in metastasis of canine breast tumours was not effective. Knowing the positive effects that some studies showed in mammary gland tumours treated with progesterone antagonist in other species; do not rule out that another treatment schedule might have a benefi cial effect on the female dog.

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How to Cite
Hermo, G., Villanueva, M., Segura, P., Alonso, D., & Gobello, C. (2009). Assessment of aglepristone in dogs with mammary tumors stage V. Anales de Veterinaria de Murcia, 25, 87–96. Retrieved from https://revistas.um.es/analesvet/article/view/100211
Issue
Vol. 25 (2009)
Section
Trabajos Fin de Grado/Fin de Máster

 

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