Abnormal distribution of CD45 isoforms expressed by CD4+ and CD8+ T cells in rheumatoid arthritis

Authors

  • Pierre Youinou
  • A. Mamoune
  • V. Durand
  • P. Le Goff
  • Y. L. Pennec
  • R. Le Corre

Keywords:

CD45 isoform, T cell, rheumatoid arthritis, apoptosis

Abstract

CD45RO+ T cells are referred to as memory or helper-inducer while CD45RA+ T cells are regarded as naive or suppressor-inducer T cells. The former population predominates in the peripheral blood and even more in the synovial fluid of patients with rheumatoid arthritis, to the expense of the latter population. Within the CD45RB+ compartment, there appears to be more of the fully-differentiated than of the early-differentiated CD4+ T cells. In spite of the fact that these lymphocytes are close to undergoing apoptosis, this programmed cell death is inhibited in the rheumatoid synovium.

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Invited Reviews