Human lung fructose-1,6-bisphosphatase is localized in pneumocytes II

Authors

  • Andrzej Dzugaj
  • A. Gizak
  • D. Rakus
  • J. Kolodziej
  • M. Zabel
  • A. Ogorzalek

Keywords:

fructose-1, 6-bisphosphatase, immunocytochemistry, lung, pneumocytes

Abstract

The localization of fructose-1,6-bisphosphatase (Fru-1,6-Pase EC 3.1.3.11) in human alveolar epithelium was determined immunohistochemically using a polyclonal antibody raised against the enzyme purified from human liver. The immunohistochemical analysis revealed that the Fru-1,6-Pase was localized in pneumocytes 11 and was absent in pneumocytes 1. Hypothetically Fru-1,6-Pase participating in glucose-6-phosphate synthesis from noncarbohydrate precursors increases NADPH leve1 which is used for surfactant synthesis and for glutathione redox cycle.

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