Recent progress in T-cadherin (CDHI 3, H-cadherin) research

  • Tamotsu Takeuchi
  • Y. Ohtsuki
Keywords: T-cadherin, cancer, angiogenesis, neuron, alveolar proteinosis


T-cadherin is a unique cadherin cell adhesion molecule that is anchored to the cell surface membrane through a glycosyl phosphatidyl inositol (GPI) moiety. The cytoplasmic domain, which T-cadherin lacks, is believed to be critical for homophilic binding through interaction with submembrane cytoskeletal proteins. Docs this mean that T-cadherin is an unimportant molecule'? However, the T-cadherin amino acid motif has been well conserved through evolution in vertebrates, suggesting that T-cadherin may have biological significance in higher animals. Consistent with this hypothesis, recent studies have thrown light on the relevance of T-cadherin in the fields of ontology, neurology, respirology and cardiovascular physiology. In this manuscript, we review current advances In Tcadherin research.