PAIN MANAGEMENT IN OSTEOARTHRITIS THROUGH THERAPIES WITH MONOCLONAL ANTIBODIES VERSUS CONVENTIONAL ANALGESICS

Authors

  • Alba Tomás-Macanás Departamento de Farmacología. Facultad de Veterinaria. Universidad de Murcia.
  • Carlos-Mario Cárceles-Rodríguez Departamento de Farmacología. Facultad de Veterinaria. Universidad de Murcia.
DOI: https://doi.org/10.6018/analesvet.623981
Keywords: Nerve Growth Factor, analgesia, pronociceptive receptors, monoclonal antibodies, treatment

Abstract

Osteoarthritis is a degenerative joint disease that affects a large part of small animal clinic patients, regardless of their age. However, the importance of this pathology lies in the pain it causes in patients, which can reduce their quality of life. Nerve Growth Factor (NGF) binds to the high affinity receptor TrkA to form the NGF/TrkA complex responsible for overexpressing pronociceptive neurotransmitters. Therefore, the regulation of NGF/TrkA signaling is essential in the management of patients' pain. Frunevetmab (Solensia®) and bedinvetmab (Librela®) are two drugs currently used to reduce chronic pain caused by osteoarthritis, since they are inhibitors of this NGF. However, drugs such as low-dose NSAIDs, gabapentin or opioids have been shown to control the animal's chronic pain in the long term. However, despite having a positive benefit-risk balance in the animal, they can cause various adverse effects that monoclonal antibodies do not have. In this research, five studies have been analyzed, three where efficacy and safety are observed in the feline species and two studies intended for the canine species, in which it is observed that the animals to which monoclonal antibodies are administered show improvement in the clinical signs for one month after administration, compared to placebo groups.

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Published
05-05-2025
How to Cite
Tomás-Macanás, A., & Cárceles-Rodríguez, C.-M. (2025). PAIN MANAGEMENT IN OSTEOARTHRITIS THROUGH THERAPIES WITH MONOCLONAL ANTIBODIES VERSUS CONVENTIONAL ANALGESICS. Anales De Veterinaria De Murcia, 39. https://doi.org/10.6018/analesvet.623981
Issue
Vol. 39 (2025)
Section
Trabajos Fin de Grado/Fin de Máster

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